Shigella Stays on the Move

Slides:

Advertisements

Similar presentations

Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut Patrick H. Degnan, Natasha A. Barry, Kenny C. Mok,

Advertisements

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans Amy G. Hise, Jeffrey Tomalka, Sandhya Ganesan,

Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription Chia-Hsin.

Genes Induced Late in Infection Increase Fitness of Vibrio cholerae after Release into the Environment Stefan Schild, Rita Tamayo, Eric J. Nelson, Firdausi.

The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin- Dependent Autophagy of Intracellular Salmonella Typhimurium Alan Huett, Robert.

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.

Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming Smita Srivastava, Joel D. Ernst Cell Host & Microbe Volume 15, Issue 6,

Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7 Hyun.

Volume 16, Issue 4, Pages (October 2014)

H. pylori GPS: Modulating Host Metabolites for Location Sensing

RAS and ROS—A Story of Pseudomonas Survival

Interferons Coordinate a Multifaceted Defense

Trained Immunity: An Ancient Way of Remembering

P Bodies, Stress Granules, and Viral Life Cycles

Strength in Diversity Cell Host & Microbe

Enterococcus faecalis: E. coli’s Siderophore-Inducing Sidekick

The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost

A Way to DAI Cell Host & Microbe

Monocyte-Plasmablast Crosstalk during Dengue

P Bodies, Stress Granules, and Viral Life Cycles

The Fungal Mycobiota: Small Numbers, Large Impacts

NMD: Nonsense-Mediated Defense

Bacterial Reductionism: Host Thiols Enhance Virulence

Shigella Gets Captured to Gain Entry

Volume 20, Issue 4, Pages (October 2016)

Warfare between Host Immunity and Bacterial Weapons

Unsweetened IgG Is Bad for Dengue Patients

Arturo Casadevall, Liise-anne Pirofski Cell Host & Microbe

Portrait of a Killer: Genome of the 2014 EBOV Outbreak Strain

Candida albicans Adds More Weight to Iron Regulation

Shigella Targets T Cells

Octavio Ramilo, Asunción Mejías Cell Host & Microbe

A Greasy Foothold for Helicobacter pylori

Jonathan B. Muyskens, Karen Guillemin Cell Host & Microbe

Autophagy, Apoptosis, and the Influenza Virus M2 Protein

A Microbiome Foundation for the Study of Crohn’s Disease

Epithelial Sensing of Fungal Invasion

Type VI Secretion: Not Just for Pathogenesis Anymore

Volume 22, Issue 3, Pages (September 2017)

Monocyte-Plasmablast Crosstalk during Dengue

Arturo Casadevall, Liise-anne Pirofski Cell Host & Microbe

A Serpin Takes a Bite out of the Flu

The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost

Volume 22, Issue 4, Pages e5 (October 2017)

Gut Check: IFNγ Delays Mucosal Recovery during Antibiotic Therapy

Jonathan D. Licht, Jake Shortt, Ricky Johnstone Cancer Cell

Double Trouble: HIV Latency and CTL Escape

Copyright © 2013 Elsevier Inc. All rights reserved.

Recognizing Macrophage Activation and Host Defense

Caging Targets for Destruction

Gut Microbes Take Their Vitamins

Linking Inflammasome Activation and Phagosome Maturation

Flying Under the Radar: Immune Evasion by Group B Streptococcus

A Microbiome Foundation for the Study of Crohn’s Disease

Taking Sides: Interferons in Leprosy

Inside Job: Viruses Transfer cGAMP between Cells

Volume 16, Issue 2, Pages (August 2014)

The Yeast Saccharomyces cerevisiae: A Versatile Model System for the Identification and Characterization of Bacterial Virulence Proteins Keri A. Siggers,

Shigella Navigates Tight Corners

For HIV, It's Never Too Late to Grow Up

Wilbert Bitter, Coen Kuijl Cell Host & Microbe

Viral Suppressors of RNA-Based Viral Immunity: Host Targets

Volume 16, Issue 4, Pages (October 2014)

Streptococcus pyogenes Escapes from Autophagy

A Commensal Protozoan Strikes a Balance in the Gut

Two Tales (Tails) of SAMHD1 Destruction by Vpx

The Mammalian Gut as a Matchmaker

A Host MicroRNA Brokers Truce with HSV-1

Host and Microbes Date Exclusively

Presentation transcript:

Shigella Stays on the Move Noelia Lopez-Montero, Jost Enninga Cell Host & Microbe Volume 22, Issue 4, Pages 432-433 (October 2017) DOI: 10.1016/j.chom.2017.09.013 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 GBPs Restrict Shigella Motility in IFNγ-Stimulated Epithelial Cells After inducing its own uptake, Shigella escapes from the bacteria-containing vacuole and assembles an actin tail to move from cell to cell (upper half of the figure). IFNγ induces the expression of GBPs that encage the cytosolic bacteria and prevent actin tail formation. Shigella injects the E3 ligase IpaH9.8 to neutralize this host defense response. IpaH9.8 ubiquitylates GBPs, which are targeted to proteasomal degradation, allowing the restoration of bacterial motility (lower half of the figure). Cell Host & Microbe 2017 22, 432-433DOI: (10.1016/j.chom.2017.09.013) Copyright © 2017 Elsevier Inc. Terms and Conditions