The Troubled Touch of Autism

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The Troubled Touch of Autism Alexander H. Tuttle, Victoria B. Bartsch, Mark J. Zylka Cell Volume 166, Issue 2, Pages 273-274 (July 2016) DOI: 10.1016/j.cell.2016.06.054 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Deletion of Mecp2 in Peripheral Sensory Ganglia Is Sufficient to Produce Some Autism-Related Phenotypes. (A–C) Mecp2 mutation (A) in the indicated tissues (B) (red X) caused behavioral changes (C) relative to wild-type mice (green plus sign). “Abnormal touch” denotes problems with tactile discrimination, tactile prepulse inhibition, and hypersensitivity to gentle tactile stimuli. “Social deficits” include deficits in sociability, social novelty, and social approach. “Anxiety” signifies reduced exploration in an open field and failure to habituate to repeat presentations of a startling tone. Cell 2016 166, 273-274DOI: (10.1016/j.cell.2016.06.054) Copyright © 2016 Elsevier Inc. Terms and Conditions