The effects of dynamic cardiac compression on ventricular mechanics and energetics: Role of ventricular size and contractility Osamu Kawaguchi, MD, Yoichi.

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Date of download: 9/16/2016 Copyright © The American College of Cardiology. All rights reserved. From: Oxygen-Saving Effect of a New Cardiotonic Agent,

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Presentation transcript:

The effects of dynamic cardiac compression on ventricular mechanics and energetics: Role of ventricular size and contractility Osamu Kawaguchi, MD, Yoichi Goto, MD, Shiho Futaki, MD, Yuichi Ohgoshi, MD, Hitoshi Yaku, MD, Hiroyuki Suga, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 107, Issue 3, Pages 850-859 (March 1994) DOI: 10.5555/uri:pii:S0022522394703418 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Schematic diagram of excised, cross-circulated heart preparation. AVO 2, Arteriovenous oxygen content difference analyzer; DC Pressure, dynamic compression pressure; ECG, electrocardiogram; LV, left ventricle; LV Pressure, left ventricular pressure. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 850-859DOI: (10.5555/uri:pii:S0022522394703418) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Schematic illustration of ventricular P-V loop, systolic PVA, EW, and end-systolic potential energy (PE). ESPVR, End-systolic P-V relation; EDPVR, end-diastolic P-V relation;V0, volume axis intercept of ESPVR. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 850-859DOI: (10.5555/uri:pii:S0022522394703418) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 A, Simultaneous tracings of left ventricular pressure(LVP), left ventricular volume (LVV), dynamic compression pressure (DCP), left ventricular epicardial electrocardiogram (ECG), coronary blood flow (CBF),and coronary arteriovenous O2 content difference(AVOX) in control and DCC contractions. P-V loops of control and DCC contractions. Dashed diagonal lines are Emax lines of these contractions. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 850-859DOI: (10.5555/uri:pii:S0022522394703418) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Comparison of incremental variables by DCC in small and large volume runs. ΔEW, Increases in external mechanical work; ΔPVA, increases in PVA; NS, statistically insignificant; L, large volume; S, small volume. Means ± standard error of mean are indicated (n = 10). *p < 0.01. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 850-859DOI: (10.5555/uri:pii:S0022522394703418) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 5 Comparison of incremental variables by DCC in control, dobutamine, and propranolol runs. ΔDCP, Increases in dynamic compression pressure; ΔEmax, increases in Emax; ΔEW, increases in EW; ΔPes, increases in end-systolic pressure; ΔPVA, increases in PVA; ΔVO 2, increases in myocardial oxygen consumption; NS, statistically insignificant. Means plus or minus standard error of mean are indicated (n = 7). The Journal of Thoracic and Cardiovascular Surgery 1994 107, 850-859DOI: (10.5555/uri:pii:S0022522394703418) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 6 A, Schematic diagram of changes in P-V loop during DCC. Dashed area represents native heart PVA during DCC. B and C, Schematic diagram of changes in P-V loop at constant stroke volume in small-sized and dilated hearts. D and E, Schematic diagram of changes in P-V loop at constant end-diastolic volume in small-sized and dilated hearts. P-V loop under DCC is estimated from native end-systolic P-V relationship. Dashed area in B through E represents decrease in native heart PVA induced by DCC. Dotted area represents increased PVA during DCC. eES, Enhanced end-systolic P-V relation line; ED, end-diastolic P-V curve; nES, native end-systolic P-V relation line; V0,volume axis intercept of ES. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 850-859DOI: (10.5555/uri:pii:S0022522394703418) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 7 A, Schematic diagram of changes in P-V loop during DCC. B and C, Schematic diagram of changes in P-V loop at constant stroke volume in small-sized and dilated hearts. P-V loop under DCC is estimated from native end-systolic P-V relationship. Dashed area represents mechanical energy provided by DCC. eES, Enhanced end-systolic P-V relation line; ED, end-diastolic P-V curve; nES, native end-systolic P-V relation line; V0, volume axis intercept of ES. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 850-859DOI: (10.5555/uri:pii:S0022522394703418) Copyright © 1994 Mosby, Inc. Terms and Conditions