Health effects of air pollution

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Presentation transcript:

Health effects of air pollution Editor: Jonathan A. Bernstein, MD, Contributors: Neil Alexis, PhD, Charles Barnes, PhD, I. Leonard Bernstein, MD, Andre Nel, MD, PhD, David Peden, MD, David Diaz-Sanchez, PhD, Susan M. Tarlo, MB, BS, P. Brock Williams, PhD Journal of Allergy and Clinical Immunology Volume 114, Issue 5, Pages 1116-1123 (November 2004) DOI: 10.1016/j.jaci.2004.08.030 Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Hierarchic oxidative stress model to PM. At tier 1, antioxidant enzymes restore cellular redox homeostasis. At tier 2, proinflammatory responses are induced. At tier 3, cellular apoptosis-necrosis occurs. GSH, Glutathione; GSSG, oxidized glutathione; NF-κB, nuclear factor κB; MAPK, mitogen-activated kinase; AP-1, Activator protein 1. Journal of Allergy and Clinical Immunology 2004 114, 1116-1123DOI: (10.1016/j.jaci.2004.08.030) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions