Cell Migration: PKA and RhoA Set the Pace Karen A. Newell-Litwa, Alan Rick Horwitz  Current Biology  Volume 21, Issue 15, Pages R596-R598 (August 2011) DOI: 10.1016/j.cub.2011.06.032 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 PKA establishes a protrusion–retraction oscillation by phosphorylating RhoA. Protrusions drive actin polymerization (blue lines) and adhesion formation (pink circles). Both Rho and PKA are active (∗) in protrusions. However, PKA phosphorylates RhoA at the leading edge and removes it from the membrane by promoting the association between RhoA and RhoGDI, leading to sequestration of RhoA in the cytosol. Retraction formation is characterized by actomyosin bundles (blue bundles) and elongating adhesions (pink ovals). Current Biology 2011 21, R596-R598DOI: (10.1016/j.cub.2011.06.032) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 2 Timeline of events during a protrusion–retraction cycle. Current Biology 2011 21, R596-R598DOI: (10.1016/j.cub.2011.06.032) Copyright © 2011 Elsevier Ltd Terms and Conditions