Volume 24, Issue 4, Pages (December 2017)

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Volume 24, Issue 4, Pages 275-279 (December 2017) Irinotecan chemotherapy-induced intestinal oxidative stress: Underlying causes of disturbed mucosal water and electrolyte transport Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki Pathophysiology Volume 24, Issue 4, Pages 275-279 (December 2017) DOI: 10.1016/j.pathophys.2017.07.002 Copyright © 2017 Elsevier B.V. Terms and Conditions

Pathophysiology 2017 24, 275-279DOI: (10.1016/j.pathophys.2017.07.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Histological examination of intestinal mucosa after irinotecan injection (200mgkg−1): (A) showed a normal mucosa with intact epithelial surface, (B) presented an epithelial destruction and inflammatory cells infiltrate and (C) indicated the histological scores for intestinal mucositis. #: p<0.05 compared to NaCl group. Values are means±SEM (n=10). Pathophysiology 2017 24, 275-279DOI: (10.1016/j.pathophys.2017.07.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Effects of a single intraperitoneal injection of irinotecan (200mgkg−1) on protein and sulfhydryl groups levels in intestinal mucosa of rats. #: p<0.05 compared to NaCl group. Values are means±SEM (n=10). Pathophysiology 2017 24, 275-279DOI: (10.1016/j.pathophys.2017.07.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Effects of a single intraperitoneal injection of irinotecan (200mgkg−1) on MDA level and MPO activity in intestinal mucosa of rats. #: p<0.05 compared to NaCl group. Values are means±SEM (n=10). Pathophysiology 2017 24, 275-279DOI: (10.1016/j.pathophys.2017.07.002) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 4 Effects of a single intraperitoneal injection of irinotecan (200mgkg−1) on enzymatic antioxidant activities (superoxide dismutase, catalase and glutathione peroxidase) in intestinal mucosa of rats. #: p<0.05 compared to NaCl group. Values are means±SEM (n=10). Pathophysiology 2017 24, 275-279DOI: (10.1016/j.pathophys.2017.07.002) Copyright © 2017 Elsevier B.V. Terms and Conditions