Decreased response to inhaled steroids in overweight and obese asthmatic children Erick Forno, MD, MPH, Rachel Lescher, MD, Robert Strunk, MD, Scott Weiss,

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Decreased response to inhaled steroids in overweight and obese asthmatic children Erick Forno, MD, MPH, Rachel Lescher, MD, Robert Strunk, MD, Scott Weiss, MD, MS, Anne Fuhlbrigge, MD, MPH, Juan C. Celedón, MD, DrPH Journal of Allergy and Clinical Immunology Volume 127, Issue 3, Pages 741-749 (March 2011) DOI: 10.1016/j.jaci.2010.12.010 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Effect of budesonide on measures of lung function and BDR by BMI group. A, Pre-FEV1 (percent predicted). B, Pre-FEV1/FVC ratio. C, BDR. Budesonide is shown as blue diamonds, and placebo and nedocromil are shown as red squares. Solid lines indicate time points where the difference between treatment arms was significant. Nonsignificant visits are shown as dotted lines. Stars show points where there was a significant difference between arms and from baseline values. Arrows and P values are for overall longitudinal effect of budesonide over months 0 to 20 or 24 to 48 compared with baseline values. Journal of Allergy and Clinical Immunology 2011 127, 741-749DOI: (10.1016/j.jaci.2010.12.010) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Effect of budesonide on asthma-related outcomes by overweight status. Lines represent the difference between treatment arms (Budesonide − Placebo/nedocromil; negative numbers indicate an improvement in the budesonide arm compared with the nonbudesonide arm). The overweight/obese group is shown as orange circles, and the nonoverweight group is shown as green triangles. A, Average number of prednisone courses per patient since the previous visit. B, Percentage of children reporting any urgent care visits or hospital admissions. Note: Solid lines/symbols represent visits where the difference was significant, and nonsignificant time points are shown as dotted lines. Journal of Allergy and Clinical Immunology 2011 127, 741-749DOI: (10.1016/j.jaci.2010.12.010) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions