Transtracheal ventilation with a novel ejector-based device (Ventrain) in open, partly obstructed, or totally closed upper airways in pigs† M. Paxian,

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Transtracheal ventilation with a novel ejector-based device (Ventrain) in open, partly obstructed, or totally closed upper airways in pigs† M. Paxian, N.P. Preussler, T. Reinz, A. Schlueter, R. Gottschall British Journal of Anaesthesia Volume 115, Issue 2, Pages 308-316 (August 2015) DOI: 10.1093/bja/aev200 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 Arterial oxygen partial pressure ( P a O 2 ) during transtracheal ventilation with Ventrain or manually hand-triggered jet ventilation (Manujet). Data are mean (sd) for both devices in open, partly obstructed, or totally closed upper airways (n=10). *P<0.05 vs Ventrain in totally closed upper airways. British Journal of Anaesthesia 2015 115, 308-316DOI: (10.1093/bja/aev200) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 Arterial carbon dioxide partial pressure ( P a C O 2 ) during transtracheal ventilation with Ventrain or manually hand-triggered jet ventilation (Manujet). Data are the mean (sd) for both devices in open, partly obstructed, or totally closed upper airway (n=10). *P<0.05 vs Ventrain in totally closed, †P<0.05 vs Ventrain in partly obstructed, and ‡P<0.05 vs Ventrain in open upper airways. British Journal of Anaesthesia 2015 115, 308-316DOI: (10.1093/bja/aev200) Copyright © 2015 The Author(s) Terms and Conditions

Fig 3 Peak airway pressure (PAW) measured during transtracheal ventilation with Ventrain or manually hand-triggered jet ventilation (Manujet). Data are mean (sd) for both devices in open, partly obstructed, or totally closed upper airways (n=10). *P<0.05 vs Ventrain in closed upper airways; †P<0.05 vs Ventrain in partly obstructed airways. British Journal of Anaesthesia 2015 115, 308-316DOI: (10.1093/bja/aev200) Copyright © 2015 The Author(s) Terms and Conditions

Fig 4 Peak airway pressure (PAW) during transtracheal ventilation with Ventrain using two different I:E ratios in partly or completely closed upper airways. Data are mean (sd). *P<0.05 in comparison with I:E ratio of 1:1. n=6 for I:E ratio of 1:2; n= 10 for I:E ratio of 1:1. British Journal of Anaesthesia 2015 115, 308-316DOI: (10.1093/bja/aev200) Copyright © 2015 The Author(s) Terms and Conditions

Fig 5 Invasively measured mean arterial blood pressure (MAP) during transtracheal ventilation with Ventrain or manually hand-triggered jet ventilation (Manujet). Data are mean (sd) for both devices in open, partly obstructed, or totally closed upper airways (n=10). *P<0.05 compared with ventilation with Manujet in partly obstructed upper airways. British Journal of Anaesthesia 2015 115, 308-316DOI: (10.1093/bja/aev200) Copyright © 2015 The Author(s) Terms and Conditions

Fig 6 Central venous pressure (CVP) during transtracheal ventilation with Ventrain or manually hand-triggered jet ventilation (Manujet). Data are mean (sd) for both devices in open, partly obstructed, or totally closed upper airways (n=10). *P<0.05 in comparison with Ventrain in totally obstructed airway; †P<0.05 compared with Ventrain in partly closed airways. British Journal of Anaesthesia 2015 115, 308-316DOI: (10.1093/bja/aev200) Copyright © 2015 The Author(s) Terms and Conditions