Antigen to the Node: B Cells Go Native

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Presentation transcript:

Antigen to the Node: B Cells Go Native David Tarlinton, Andrew Lew Immunity Volume 26, Issue 4, Pages 388-390 (April 2007) DOI: 10.1016/j.immuni.2007.04.002 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Representation of a Lymph Node Showing Pathways of Antigen Entry B cell (F, follicles) and T cell areas (PC, paracortex) are marked as are medullary sinus, high endothelial venules, afferent and efferent lymphatics, and the subcapsular sinus. Antigen enters the node either cell associated (pathway A) or free (pathway B). Pathway A results in the antigen moving within conduits (C) from the subcapsular sinus to the paracortex where it can be picked up by DC. Pathway B, described by Pape et al. (2007), concentrates free antigen in the follicles where it can activate B cells. Immunity 2007 26, 388-390DOI: (10.1016/j.immuni.2007.04.002) Copyright © 2007 Elsevier Inc. Terms and Conditions