IL-21 induces the expression of CX3CL1 in the muscle in EAM

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IL-21 induces the expression of CX3CL1 in the muscle in EAM IL-21 induces the expression of CX3CL1 in the muscle in EAM. (A–C) EAM was induced in IL-21−/− mice and WT mice. IL-21 induces the expression of CX3CL1 in the muscle in EAM. (A–C) EAM was induced in IL-21−/− mice and WT mice. (A) Mean fluorescent intensity (MFI) of indicated chemokine receptors on γδT cells in the draining LNs and the muscle. n = 3–6 mice. (B) Upper panels, Representative profiles of CD27 versus TCRγδ on γδT cells and Vδ4 versus Vγ4 on CD27− γδT cells. Middle panels, Representative histograms of CX3CR1 on indicated subsets of γδT cells. Lower panel, Mean ± SEM of MFI of CX3CR1 in indicated subsets of γδT cells. n = 6 mice. *p < 0.05, **p < 0.01. (C) The expression of Cx3cl1 mRNA in the muscle was assessed by qPCR at day 24 of EAM. Mean ± SEM. n = 7 (EAM) and 3 (PBS). *p < 0.05. (D) VISTA plot between human and mouse Cx3cl1 promoter region and putative Stat1, Stat3, and Stat5a binding sites of conserved region (green line). (E) Mean ± SEM of fold induction of Cx3cl1-Luc (n = 4). *p < 0.05. (F) The correlation between IL-21 levels and CX3CL1 levels in serum of PM/DM patients (n = 41). Spearman rank correlation coefficient was used. Takahiro Kageyama et al. ImmunoHorizons 2017;1:176-187 Copyright © 2017 The Authors