Juul – What you need to know Photo credit: JOSH VALCARCEL/WIRED

“…the I-Phone of e-cigs.” – Wired magazine, April 21, 2015 “…tap the side of the device twice, and the LED light on the front blinks an indication of your remaining battery.” “It charges in a tiny dock that slips into any USB slot, and there's something wonderfully satisfying about dropping it into the magnetic charger.” Exerpts from: https://www.wired.com/2015/04/pax-juul-ecig/ Photo: www.Juulvapor.com “If you wave the Juul around, it lights up in a rainbow of colors.” https://www.wired.com/2015/04/pax-juul-ecig/

Current* Juul FLAVORS “Flavor Guide”-- 59 mg/mL nicotine per ‘pod’ Mango. Ripe mango with hints of tropical fruit. Cool Mint. Crisp peppermint with a soothing aftertaste. Virginia Tobacco. Rich, unmistakable tobacco. Fruit Medley. Peaches, grapes and berries with herbal notes. Creme Brulee. Vanilla cake, silky custard and crème brulee. Limited Edition Classic Tobacco. Familiar, robust tobacco flavor with aromatic notes. Limited Edition Classic Menthol. Traditional menthol flavor with a brisk finish. Limited Edition Cool Cucumber. Cucumber with a hint of mint. From the juulvapor.com website www.juulvapor.com *accessed 4-4-2018

According to this article, mango flavor was added after the Juul was originally released, and it quickly became its most popular flavor among members of this website. http://vaping360.com/juul-pods/

Juulpod Juice - Ingredients Our ingredients include glycerol, propylene glycol, natural oils, extracts and flavor, nicotine and benzoic acid. Glycerol and Propylene Glycol have commonly used humectants in vaporization liquids, and also used in a number of consumer products like toothpaste. Benzoic Acid is a naturally occurring acid found in the tobacco plant, which is a part of our proprietary formulation that makes JUUL the ultimate vaping experience. As a policy, our development and manufacturing process does not add diacetyl and acetylproprionyl (or 2,3-pentanedione) as flavor ingredients. Nicotine content: 0.7mL with 5% nicotine by weight (59 mg/mL per pod, ~ content of a pack of cigarettes). https://support.juulvapor.com/home/learn/faqs/juulpods-juice

…other e-cigs provide half as much nicotine on average. Juuls are designed to produce as much nicotine as a cigarette with each puff… Article: https://offspring.lifehacker.com/what-parents-need-to-know-about-juuling-1823376027 Quote from comment in this article: https://www.buzzfeed.com/carolinekee/juul-ecigarette-vape-health-effects?utm_term=.mpNwBYwzKv#.ubvYQLYJ37 Photo: Getty Images …other e-cigs provide half as much nicotine on average. “…at our school they call it the devil's usb lmao”

How do nicotine salts work in e-liquid? http://vaping360.com/nicotine-salts-e-liquid/ http://vaping411.com/nicotine-salts/ This graph shows the Pax Labs test achieved similar blood nicotine content as traditional smoking. Image Credit: Engadget

Reasons why Juul e-cigs are popular with youth: Discreet Trendy Looks like a flash drive Comes in fun flavors Gives a good “buzz” or head rush Quote from article: https://www.buzzfeed.com/carolinekee/juul-ecigarette-vape-health-effects?utm_term=.mpNwBYwzKv#.ubvYQLYJ37 Photo from article: Getty Images “i dropped my juul once and a kid picked it up and said here you dropped your lead holder for mechanical pencils”

PUBLIC HEALTH CONSEQUENCES OF E-CIGARETTES Conclusion 14-1. There is conclusive evidence that e-cigarette devices can explode and cause burns and projectile injuries. Such risk is significantly increased when batteries are of poor quality, stored improperly or are being modified by users Conclusion 7-1. There is substantial evidence that e-cigarette aerosols can induce acute endothelial cell dysfunction, although the long-term consequences and outcomes on these parameters with long-term exposure to e-cigarette aerosol are uncertain. Conclusion 8-1. There is substantial evidence that e-cigarette use results in symptoms of dependence on e-cigarettes Conclusion 16-1. There is substantial evidence that e-cigarette use increases risk of ever using combustible tobacco cigarettes among youth and young adults. Conclusion 11-4. There is moderate evidence for increased cough and wheeze in adolescents who use e-cigarettes and an association with e-cigarette use and an increase in asthma exacerbations. Research info: https://www.nap.edu/resource/24952/012318ecigaretteConclusionsbyEvidence.pdf Levels of Evidence Defined: Conclusive evidence: There are many supportive findings from good-quality controlled studies (including randomized and non-randomized controlled trials) with no credible opposing findings. A firm conclusion can be made, and the limitations to the evidence, including chance, bias, and confounding factors, can be ruled out with reasonable confidence. Substantial evidence: There are several supportive findings from good-quality observational studies or controlled trials with few or no credible opposing findings. A firm conclusion can be made, but minor limitations, including chance, bias, and confounding factors, cannot be ruled out with reasonable confidence. Moderate evidence: There are several supportive findings from fair-quality studies with few or no credible opposing findings. A general conclusion can be made, but limitations, including chance, bias, and confounding factors, cannot be ruled out with reasonable confidence. Conclusion 16-2. Among youth and young adult e-cigarette users who ever use combustible tobacco cigarettes, there is moderate evidence that e-cigarette use increases the frequency and intensity of subsequent combustible tobacco cigarette smoking. https://www.nap.edu/