D Latzke, P Marhofer, M Zeitlinger, A Machata, F Neumann, E Lackner, S

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Presentation transcript:

Minimal local anaesthetic volumes for sciatic nerve block: evaluation of ED99 in volunteers D Latzke, P Marhofer, M Zeitlinger, A Machata, F Neumann, E Lackner, S.C. Kettner British Journal of Anaesthesia Volume 104, Issue 2, Pages 239-244 (February 2010) DOI: 10.1093/bja/aep368 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Cross-sectional view of the sciatic nerve at the mid-femoral level, where the cross-sectional area (A), the depth (B), and the circumference (C) are measured. British Journal of Anaesthesia 2010 104, 239-244DOI: (10.1093/bja/aep368) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 In-line needle guidance technique for the ultrasound-guided block of the sciatic nerve at the mid-femoral level. British Journal of Anaesthesia 2010 104, 239-244DOI: (10.1093/bja/aep368) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 The up-and-down sequence of volumes of mepivacaine 1.5% to achieve a sensory block of the sciatic nerve. The injected volume of local anaesthetic in ml mm−2 cross-sectional nerve area is shown in each volunteer. British Journal of Anaesthesia 2010 104, 239-244DOI: (10.1093/bja/aep368) Copyright © 2010 The Author(s) Terms and Conditions

Fig 4 Correlation of the volume of 1.5% mepivacaine mm−2 cross-sectional nerve area vs probability for complete sensory blocks within 45 min. Squares represent observed cases; size of squares indicates the number of cases for the respective volume (between 1 and 5). The line indicates fit by a probit model function. British Journal of Anaesthesia 2010 104, 239-244DOI: (10.1093/bja/aep368) Copyright © 2010 The Author(s) Terms and Conditions

Fig 5 Correlation of the volume of 1.5% mepivacaine mm−2 cross-sectional nerve area and time to a complete sensory block. The line represents fit by linear regression (r=0.14, P=0.63). Only subjects with successful blocks are shown. British Journal of Anaesthesia 2010 104, 239-244DOI: (10.1093/bja/aep368) Copyright © 2010 The Author(s) Terms and Conditions

Fig 6 Correlation of the volume of 1.5% mepivacaine mm−2 cross-sectional nerve area and duration of sensory block. The line represents fit by linear regression (r=0.65, P=0.003). British Journal of Anaesthesia 2010 104, 239-244DOI: (10.1093/bja/aep368) Copyright © 2010 The Author(s) Terms and Conditions

Fig 7 Cross-sectional view of the sciatic nerve at the mid-femoral level with the local anaesthetic covering the posterior aspect of the nerve. The local anaesthetic solution is indicated with the arrows. The successful block was performed with 0.1 ml mm−2 cross-sectional nerve area (=5.1 ml total volume of local anaesthetic). British Journal of Anaesthesia 2010 104, 239-244DOI: (10.1093/bja/aep368) Copyright © 2010 The Author(s) Terms and Conditions