The Tail End of Membrane Insertion

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The Tail End of Membrane Insertion Elisabet C. Mandon, Reid Gilmore Cell Volume 128, Issue 6, Pages 1031-1032 (March 2007) DOI: 10.1016/j.cell.2007.03.001 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Cotranslational and Posttranslational Integration of Membrane Proteins Partitioning of newly synthesized membrane proteins between the SRP-dependent cotranslational pathway and the TRC-dependent posttranslational pathway is determined by the location of the transmembrane span (N- or C-terminal) and the interaction between SRP and the ribosome. A subset of tail-anchored (TA) proteins (e.g., cytochrome b5) can integrate in a TRC- and TA-integrase-independent reaction. Nucleotide binding and hydrolysis reactions regulate assembly and disassembly of complexes between targeting receptors and membrane components. Cell 2007 128, 1031-1032DOI: (10.1016/j.cell.2007.03.001) Copyright © 2007 Elsevier Inc. Terms and Conditions