Volume 136, Issue 3, Pages 863-871 (March 2009) Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy  Peter Iversen, Michael Sørensen, Lasse Kristoffer Bak, Helle Sønderby Waagepetersen, Manouchehr Seyedi Vafaee, Per Borghammer, Kim Mouridsen, Svend Borup Jensen, Hendrik Vilstrup, Arne Schousboe, Peter Ott, Albert Gjedde, Susanne Keiding  Gastroenterology  Volume 136, Issue 3, Pages 863-871 (March 2009) DOI: 10.1053/j.gastro.2008.10.057 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 CMRO2 in whole brain, gray matter, and white matter (A) and in 7 predefined brain regions (B). Groups of subjects comprise 6 cirrhotic patients with an acute episode of overt HE (●), 6 cirrhotic patients without HE (), and 7 healthy subjects (♢). Results are shown as mean ± SEM. (C) Comparison of voxel-based mean CMRO2 in cirrhotic patients with HE and cirrhotic patients without HE by means of a voxel-based statistical t image superimposed on an MR image. Areas with t values for P < .05 are shown in blue. R, right side; L, left side; A, anterior; P, posterior. Gastroenterology 2009 136, 863-871DOI: (10.1053/j.gastro.2008.10.057) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 CBF in whole brain, gray matter, and white matter (A) and in 7 predefined brain regions (B). Groups of subjects comprise 6 cirrhotic patients with overt HE (●), 6 cirrhotic patients without HE (), and 7 healthy subjects (♢). (C) Comparison of mean voxel-based CBF in cirrhotic patients with HE and cirrhotic patients without HE by a voxel-based statistical t image superimposed on an MR image. Areas with t values for P < .05 are shown in blue. R, right side; L, left side; A, anterior; P, posterior. Gastroenterology 2009 136, 863-871DOI: (10.1053/j.gastro.2008.10.057) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Individual values of whole-brain CMRO2 plotted against CBF in cirrhotic patients with HE (●), cirrhotic patients without HE (), and healthy subjects (♢). Gastroenterology 2009 136, 863-871DOI: (10.1053/j.gastro.2008.10.057) Copyright © 2009 AGA Institute Terms and Conditions

Figure 4 Individual values of whole-brain CMRO2 versus arterial plasma concentration of ammonia (A) and versus arterial pCO2 (B). Individual values of whole-brain CBF versus arterial plasma concentration of ammonia (C) and versus arterial pCO2 (D). Patient groups are cirrhotic patients with HE (●), cirrhotic patients without HE (), and healthy subjects (♢). Gastroenterology 2009 136, 863-871DOI: (10.1053/j.gastro.2008.10.057) Copyright © 2009 AGA Institute Terms and Conditions