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Presentation transcript:

Supplementary material Targeting amino acid metabolism for cancer therapy Michael J. Lukey1, William P. Katt1 and Richard A. Cerione1,2,*   1Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA 2Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA *Corresponding author: Cerione, R.A. (rac1@cornell.edu).

Table S1. Amino acid and selected metabolite concentrations in blood serum, selected tissues, HeLa cells, and culture media References Takach, E. et al. (2014) High-throughput quantitation of amino acids in rat and mouse biological matrices using stable isotope labeling and UPLC-MS/MS analysis. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 964,180-190 Psychogios, N. et al. (2011) The human serum metabolome. PLoS One 6, e16957 Halámková, L. et al. (2012) Enzymatic analysis of a-ketoglutarate – a biomarker for hyperammonemia. Talenta 100, 7-11 Filho, J.C. et al. (1997) Simultaneous measurements of free amino acid patterns of plasma, muscle and erythrocytes in healthy human subjects. Clin. Nutr. 16, 299-305 Montanari, A. et al. (1988) Free amino acids in plasma and skeletal muscle of patients with liver cirrhosis. Hepatology 8, 1034-1039 Roth, E. et al. (1985) Amino acid concentrations in plasma and skeletal muscle of patients with acute hemorrhagic necrotizing pancreatitis. Clin. Chem. 31, 1305-1309 Barle, H. et al. (1996) The concentrations of free amino acids in human liver tissue obtained during laproscopic surgery. Clin. Physiol. 16, 217-227 Kami, K. et al. (2013) Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry. Metabolomics 9, 444-453 Hirayama, A. et al. (2009) Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 69, 4918-4925 Chen, W. et al. (2016) Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism. Cell 166, 1324-1337