Volume 387, Issue 10033, Pages (May 2016)

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Presentation transcript:

Volume 387, Issue 10033, Pages 2093-2105 (May 2016) RETRACTED: Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis Bruno R da Costa, PhD, Stephan Reichenbach, MD, Noah Keller, MMed, Linda Nartey, MD, Simon Wandel, PhD, Prof Peter Jüni, MD, Dr Sven Trelle, MD The Lancet Volume 387, Issue 10033, Pages 2093-2105 (May 2016) DOI: 10.1016/S0140-6736(16)30002-2 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Network of comparisons included in the analyses The size of every circle is proportional to the number of randomly assigned patients and indicates the sample size. The width of the lines corresponds to the number of trials. 01=placebo. 02=paracetamol <2000 mg. 03=paracetamol 3000 mg. 04=paracetamol 3900–4000 mg. 05=rofecoxib 12·5 mg. 06=rofecoxib 25 mg. 07=rofecoxib 50 mg. 08=lumiracoxib 100 mg. 09=lumiracoxib 200 mg. 10=lumiracoxib 400 mg. 11=etoricoxib 30 mg. 12=etoricoxib 60 mg. 13=etoricoxib 90 mg. 14=diclofenac 70 mg. 15=diclofenac 100 mg. 16=diclofenac 150 mg. 17=celecoxib 100 mg. 18=celecoxib 200 mg. 19=celecoxib 400 mg. 20=naproxen 750 mg. 21=naproxen 1000 mg. 22=ibuprofen 1200 mg. 23=ibuprofen 2400 mg. The Lancet 2016 387, 2093-2105DOI: (10.1016/S0140-6736(16)30002-2) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 2 Estimates of the treatment effects on pain for different daily doses of NSAIDs and paracetamol compared with placebo Analysis considers data from all timepoints as available. Area between dashed lines shows the treatment effect estimates below the minimum clinically important difference. Two-sided p values are derived from tests of linear dose–effect. NSAID=non-steroidal anti-inflammatory drug. CrI=credibility interval. *Maximum approved daily dose. The Lancet 2016 387, 2093-2105DOI: (10.1016/S0140-6736(16)30002-2) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 3 Median rank, probability of reaching MID, and SUCRA values of competing interventions and daily doses MID=minumum clinically important difference. SUCRA=surface under the cumulative ranking curve. CrI=credibility interval. *Maximum daily dose The Lancet 2016 387, 2093-2105DOI: (10.1016/S0140-6736(16)30002-2) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 4 Estimates of the treatment effects on physical function for different daily doses of NSAIDs and paracetamol compared with placebo Analysis considers data from all timepoints as available. Area between dashed lines shows treatment effect estimates below the minimum clinically important difference. NSAID=non-steroidal anti-inflammatory drug. CrI=credibility interval. *Maximum approved daily dose. The Lancet 2016 387, 2093-2105DOI: (10.1016/S0140-6736(16)30002-2) Copyright © 2016 Elsevier Ltd Terms and Conditions