Filling the (SR)GAP in Excitatory/Inhibitory Balance

Slides:

Advertisements

Similar presentations

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Advertisements

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

GDE2 Regulates Subtype-Specific Motor Neuron Generation through Inhibition of Notch Signaling Priyanka Sabharwal, Changhee Lee, Sungjin Park, Meenakshi.

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging Iván J. Cajigas, Georgi Tushev, Tristan J. Will,

Auditory Hair Cell-Afferent Fiber Synapses Are Specialized to Operate at Their Best Frequencies M.E. Schnee, D.M. Lawton, D.N. Furness, T.A. Benke, A.J.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Normal Movement Selectivity in Autism Ilan Dinstein, Cibu Thomas, Kate Humphreys, Nancy Minshew, Marlene Behrmann, David J. Heeger Neuron Volume 66, Issue.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others Jason P. Mitchell, C. Neil Macrae, Mahzarin R. Banaji Neuron.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Rare Inherited Variation in Autism: Beginning to See the Forest and a Few Trees Jason L. Stein, Neelroop N. Parikshak, Daniel H. Geschwind Neuron Volume.

Patterning Spinal Motor Activity in the Absence of Synaptic Excitation

Presynaptic Proteoglycans: Sweet Organizers of Synapse Development

Volume 49, Issue 6, Pages (March 2006)

Steven A. Sloan, Ben A. Barres Neuron

Conventional Synapses for Unconventional Cells

Daniel R. Croft, Michael F. Olson Cancer Cell

Aphroditi A. Mamaligas, Christopher P. Ford Neuron

Healing Pains of the Past Using Neuronal Transplantation

Calcium Signaling and the Control of Dendritic Development

Volume 71, Issue 5, Pages (September 2011)

Calcium Signals Control Wnt-Dependent Dendrite Growth

Volume 49, Issue 1, Pages 1-2 (January 2006)

Kv1.1 Takes a deTOR from the Axon to the Dendrite

Nipping Fear in the Bud: Inhibitory Control in the Amygdala

Zoltán Molnár, Elek Molnár Neuron

Volume 90, Issue 3, Pages (May 2016)

“MAPseq”-uencing Long-Range Neuronal Projections

Dissonant Synapses Shall Be Punished

New Neurons Don’t Talk Back

Signaling Endosomes Trigger Synapse Assembly

The Emerging Field of Neuroepigenetics

There's More Than One Way to Scale a Synapse

Volume 68, Issue 2, Pages (October 2010)

Julien Courchet, Franck Polleux Neuron

Tommy L. Lewis, Franck Polleux Neuron

Myosin Learns to Recruit AMPA Receptors

Learning about Synaptic GluA3

K+ Channel Regulation of Multicompartmental Signal Integration

Aligning a Synapse Neuron

Timing Rules for Synaptic Plasticity Matched to Behavioral Function

Sacha B. Nelson, Vera Valakh Neuron

Ferret Interneurons Defy Expectations

Activity-Dependent Synaptogenesis in the Adult Mammalian Cortex

Volume 91, Issue 2, Pages (July 2016)

Volume 89, Issue 4, Pages (February 2016)

Volume 74, Issue 2, Pages (April 2012)

Protected by a Fox Neuron Volume 98, Issue 1, Pages 3-5 (April 2018)

Axon Trapping: Constructing the Visual System One Layer at a Time

Volume 91, Issue 6, Pages (September 2016)

Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease Michael S. Levine, Carlos Cepeda,

Matthew S. Kayser, Mark J. Nolt, Matthew B. Dalva Neuron

Cortical Cliques: A Few Plastic Neurons Get All the Action

Martin Heine, Anna Karpova, Eckart D. Gundelfinger Neuron

AgRP in energy balance: Will the real AgRP please stand up?

Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor 1

When Acetylcholine Unlocks Feedback Inhibition in Cortex

Raphe Circuits on the Menu

David Hubel and Torsten Wiesel

Biological Functions of Activity-Dependent Transcription Revealed

Presentation transcript:

Filling the (SR)GAP in Excitatory/Inhibitory Balance Jaichandar Subramanian, Elly Nedivi Neuron Volume 91, Issue 2, Pages 205-207 (July 2016) DOI: 10.1016/j.neuron.2016.07.008 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 SRGAP2A-Mediated Regulation of Excitatory and Inhibitory Synapse Density and Maturation In normal mice, excitatory and inhibitory synapses increase in size during development and reach adult levels by the late postnatal period (left panel). The FBAR and SH3 domains of SRGAP2A promote maturation of dendritic spines and inhibitory synapses, respectively. The Rho-GAP domain suppresses clustering of Gephyrin and initiation of new spines. When SRGAP2A is knocked down or is antagonized by SRGAP2C expression (right panel), Rho-GAP-mediated suppression is relieved and the density of spines and Gephyrin clusters increases. Loss of FBAR and SH3 domain function delays all synaptic maturation. Synapse maturation is protracted as compared to wild-type, but synapses reach wild-type size by adulthood. Consequently, adult synaptic densities are elevated, but excitatory/inhibitory ratios are maintained. Neuron 2016 91, 205-207DOI: (10.1016/j.neuron.2016.07.008) Copyright © 2016 Elsevier Inc. Terms and Conditions