Human NK cells can control CMV infection in the absence of T cells

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by Paul A. Carpenter, Meei-Li Huang, and George B. McDonald

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Human NK cells can control CMV infection in the absence of T cells by Taco W. Kuijpers, Paul A. Baars, Carole Dantin, Mirjam van den Burg, Rene A. W. van Lier, and Eddy Roosnek Blood Volume 112(3):914-915 August 1, 2008 ©2008 by American Society of Hematology

Kinetics of NK-cell expansion and cytokine serum-levels in relation to viral load, and phenotype of the expanded NK cells. Kinetics of NK-cell expansion and cytokine serum-levels in relation to viral load, and phenotype of the expanded NK cells. (A) Number of CMV-DNA copies (■-■) and number of NK cells (◇-◇). The number of NK in the last sample (day 50) is at the upper limit of that in normal age-matched controls. → indicates the first day of oral valganciclovir given to maintain CMV suppression. (B,C) Serum cytokine-levels during viremia (, day 9 in panel A) and in a late CMV-DNA free sample (, day 43 in panel A). □ depicts the mean value plus or minus SD in 10 healthy controls. (D) FACS analysis of the respective marker with gates on CD3-CD56+ lymphocytes. Taco W. Kuijpers et al. Blood 2008;112:914-915 ©2008 by American Society of Hematology