Endosome-Specific Localization and Function of the ARF Activator GNOM

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Endosome-Specific Localization and Function of the ARF Activator GNOM Juan S. Bonifacino, Catherine L. Jackson Cell Volume 112, Issue 2, Pages 141-142 (January 2003) DOI: 10.1016/S0092-8674(03)00038-2

Figure 1 Hypothetical Representation of the Function of GNOM GNOM is peripherally associated with the cytosolic face of endosomes, where it mediates exchange of GTP for GDP on ARF. ARF·GTP in turn recruits to the membrane a putative coat protein that effects concentration of PIN1 at sites of transport vesicle formation. Vesicles carrying PIN1 are then specifically targeted to the basal domain of the plasma membrane. The cell surface PIN1 is subsequently internalized and recycled to endosomes. Cell 2003 112, 141-142DOI: (10.1016/S0092-8674(03)00038-2)