The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta-analysis A. Osman, H. Alsomait, S. Seshadri,

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The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta-analysis A. Osman, H. Alsomait, S. Seshadri, T. El-Toukhy, Y. Khalaf Reproductive BioMedicine Online Volume 30, Issue 2, Pages 120-127 (February 2015) DOI: 10.1016/j.rbmo.2014.10.018 Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 The PRISMA flow diagram. LBR = live birth rate. Reproductive BioMedicine Online 2015 30, 120-127DOI: (10.1016/j.rbmo.2014.10.018) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Live birth rate in high and low sperm DNA fragmentation groups. ICSI = intracytoplasmic sperm injection. Reproductive BioMedicine Online 2015 30, 120-127DOI: (10.1016/j.rbmo.2014.10.018) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 A subgroup analysis in which only studies that accounted for female variables were included. (a) live birth rate in the high and low sperm DNA fragmentation groups using IVF; (b) low birth rate in the high and low DNA fragmentation groups using intracytoplasmic sperm injection. COMET = single cell gel electrophoresis assay; SCSA = sperm chromatin structure assay; TUNEL = TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labelling. Reproductive BioMedicine Online 2015 30, 120-127DOI: (10.1016/j.rbmo.2014.10.018) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions