Cyclophosphamide protects against myocardial ischemia/reperfusion injury in rats: One of the therapeutic targets is high sensitivity C-reactive protein

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Presentation transcript:

Cyclophosphamide protects against myocardial ischemia/reperfusion injury in rats: One of the therapeutic targets is high sensitivity C-reactive protein Qi-qi Wang, MD, Yuan-gang Qiu, MD, Yu-juan Zhu, MD, Jian-hua Zhu, MD, Li-hong Wang, MD, PhD, Xiao-sheng Hu, MD, PhD, Shen- jiang Hu, MD, PhD, Liang-rong Zheng, MD, PhD, Qian-min Tao, MD, Fu-rong Zhang, MD, Yun Zhang, MD The Journal of Thoracic and Cardiovascular Surgery Volume 137, Issue 4, Pages 991-996 (April 2009) DOI: 10.1016/j.jtcvs.2008.04.033 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Experimental protocol. I/R, Ischemia/reperfusion; CP, cyclophosphamide. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 991-996DOI: (10.1016/j.jtcvs.2008.04.033) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Images of infarct area: A, Twelve hours in the ischemia/reperfusion group. B, Twelve hours in the cyclophosphamide group. C, Risk area is expressed as the percentage of Evans blue–unstained area to the whole left ventricular area. D, Infarct size is expressed as the percentage of triphenyltetrazolium chloride–unstained area to Evans blue–unstained area. I/R, Ischemia/reperfusion; CP, cyclophosphamide. ∗P < .01 compared with I/R group at the same time point. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 991-996DOI: (10.1016/j.jtcvs.2008.04.033) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Hematoxylin-eosin–stained left ventricular sections from rats treated with cyclophsphamide or saline. Magnification for all images: 400×. A, HE-stained section at 3 hours in I/R group. B, HE-stained section at 3 hours in cyclophosphamide group. C, HE-stained section at 12 hours in I/R group. D, HE-stained section at 12 hours in cyclophosphamide group. E, HE-stained section at 24 hours in I/R group. F, HE-stained section at 24 hours in cyclophosphamide group. G, Damage score. I/R, Ischemia/reperfusion, CP, cyclophosphamide. ∗P < .01 compared with I/R group at the same time point; #P < .01 among different time points in I/R groups. The Journal of Thoracic and Cardiovascular Surgery 2009 137, 991-996DOI: (10.1016/j.jtcvs.2008.04.033) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions