Kazunori Kanehira, Douglas L. Riegert-Johnson, Dong Chen, Lawrence E

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FISH Diagnosis of Acute Graft-Versus-Host Disease Following Living-Related Liver Transplant Kazunori Kanehira, Douglas L. Riegert-Johnson, Dong Chen, Lawrence E. Gibson, Stephen D. Grinnell, Gopalrao V. Velgaleti The Journal of Molecular Diagnostics Volume 11, Issue 4, Pages 355-358 (July 2009) DOI: 10.2353/jmoldx.2009.080172 Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 A: Bone marrow biopsy reveals hypocellular marrow with serous degeneration. A few aggregates of erythroid precursor are seen (H&E, magnification = original ×200). B: Immunohistochemical staining for CD3 showing a cluster of T lymphocytes at peritrabecular space (magnification = original ×200). The Journal of Molecular Diagnostics 2009 11, 355-358DOI: (10.2353/jmoldx.2009.080172) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 Comparison of Giemsa-stained morphology and FISH with X-chromosome (green) and Y-chromosome (red) probes (magnification = original ×1000). A: Polychromic normoblast in bone marrow (Giemsa). B: FISH analysis of the same cell reveals XY male (donor) pattern. C: Lymphocyte in bone marrow (Giemsa). D: FISH analysis of the same cell reveals XX female (recipient) pattern. E: Activated lymphocyte in peripheral blood (Giemsa). F: FISH analysis of the same cell reveals XY male (donor) pattern. G: Band neutrophil in peripheral blood (Giemsa). H: FISH analysis of the same cell reveals XY male (donor) pattern. The Journal of Molecular Diagnostics 2009 11, 355-358DOI: (10.2353/jmoldx.2009.080172) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 3 A: Skin biopsy reveals lymphocytic infiltration in epidermis, epidermal-dermal junction and superficial perivascular spaces. Occasional keratocytes with eosinophilic necrosis are also seen in epidermis (H&E, magnification = original ×400). B: High-power view of superficial dermis with perivascular lymphocytic infiltrate (H&E, magnification = original ×1000). C: FISH analysis with X- (green) and Y-chromosome (red) probes showing mixture of XY and XX cells (magnification = original ×1000). The Journal of Molecular Diagnostics 2009 11, 355-358DOI: (10.2353/jmoldx.2009.080172) Copyright © 2009 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions