Figure 1 Osteosarcoma epidemiology Figure 1 | Osteosarcoma epidemiology. a | 5-year survival of children and young adults (aged 0–25 years) with osteosarcoma analysed in 10-year intervals is shown. Surveillance, Epidemiology, and End Results (SEER) 18 data (1973–2012) obtained from the SEER Program and analysed with SEER*Stat software version 8.3.2. b | Osteosarcoma incidence by gender is shown. SEER 18 data (1973–2013), analysed as in part a. Gianferante, D. M. et al. (2017) Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy Nat. Rev. Endocrinol. doi:10.1038/nrendo.2017.16