Volume 141, Issue 4, Pages (October 2011)

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Volume 141, Issue 4, Pages 1134-1137 (October 2011) Phenotypic Switching in Diabetic Gastroparesis: Mechanism Directs Therapy Chung Owyang Gastroenterology Volume 141, Issue 4, Pages 1134-1137 (October 2011) DOI: 10.1053/j.gastro.2011.08.014 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Pathogenesis of symptoms in diabetic gastroparesis. (1) Loss of gastric neurons containing NOS is responsible for defective accommodation reflex, leading to early satiety and postprandial fullness. (2) Impaired electromechanical activity in the myenteric plexus is responsible for delayed gastric emptying resulting in nausea and vomiting. (3) Sensory neuropathy in the gastric wall may be responsible for epigastric pain. (4) Abnormal pacemaker activity (tachybradyarrhythmia) may generate a noxious signal transmitted to the central nervous system to evoke nausea and vomiting. Gastroenterology 2011 141, 1134-1137DOI: (10.1053/j.gastro.2011.08.014) Copyright © 2011 AGA Institute Terms and Conditions