MT 5 Protein Synthesis Simple Detail:

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From: Protein Data Bank PDB ID: 1B0E Kalus, W., Zweckstetter, M., Renner, C., Sanchez, Y., Georgescu, J., Grol, M., Demuth, D., Schumacher, R., Dony, C.,
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Presentation transcript:

MT 5 Protein Synthesis Simple Detail: I will know that proteins can differ from one another in number and sequence of amino acids, shapes, and chemical properties.

Definition of Protein AA1 + AA2 + AA...+ AA1000 = protein A chain of amino acids that is used for growth, repair, and physical characteristics (eye color, hair color, skin color, etc.) AA1 + AA2 + AA...+ AA1000 = protein

Protein 1 vs Protein 2 1. Are Protein 1 and Protein 2 the same? 2. How are they different? 3. Do they have any amino acids in common?

A: They have a different shape! Protein 1 vs Protein 2

A: They have a different number of amino acids! Protein 1 vs Protein 2 21 amino acids 29 amino acids

A: They have a different sequence (order) of amino acids! Protein 1 vs Protein 2

A: They have a different chemical properties! Protein 1 vs Protein 2 Chemical Properties: proteins bind differently to other proteins, have different temperatures that can damage them, have different pH levels that can damage them, and different salt concentrations that can damage them.

Which protein binds better to Protein 3? Protein 1 Protein 2

More examples of proteins

Real examples of proteins Proteins showing their comparative sizes. From left to right are: immunoglobulin G (IgG, an antibody), hemoglobin, insulin (a hormone), adenylate kinase (an enzyme), and glutamine synthetase (an enzyme).

Protein Structure 1. Primary structure: sequence of amino acids

Protein Structure 2. Secondary Structure: amino acids form helices or sheets because of chemical attraction

Protein Structure 3. Tertiary Structure: the sheets or helices bind together bc of chemical attraction

Protein Structure Quaternary Structure: two or more subunits combine (*not all protein have this structure) http://www.youtube.com/watch?v=lijQ3a8yUYQ

Think about... 1. What causes proteins to have different shapes? 2. What cause proteins to have different chemical properties? 3. Why would nature want different types of proteins?

Think about... 1. What causes proteins to have different shapes? 2. What cause proteins to have different chemical properties? 3. Why would nature want different types of proteins? Different sequence of amino acids Different sequence of amino acids So that proteins have different functions and can have different effects on organisms.