Tailor-Made Renal Cell Carcinoma Vaccines

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Tailor-Made Renal Cell Carcinoma Vaccines Glenn Dranoff Cancer Cell Volume 22, Issue 3, Pages 287-289 (September 2012) DOI: 10.1016/j.ccr.2012.08.021 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Schema for Developing Tailor-Made Renal Cell Carcinoma Vaccines Naturally processed peptides derived from highly expressed oncogenic proteins are inoculated in conjunction with GM-CSF to stimulate tumor-specific CD8+ cytotoxic T cells. The administration of cyclophosphamide prior to vaccination attenuates FoxP3+ Tregs, resulting in more effective and durable anti-tumor immunity. High levels of apolipoprotein-A1 (APO-A1) and CCL17 are associated with superior vaccine outcome. Cancer Cell 2012 22, 287-289DOI: (10.1016/j.ccr.2012.08.021) Copyright © 2012 Elsevier Inc. Terms and Conditions