Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI Arno F. Alpi, Paul E. Pace, M. Madan Babu, Ketan J. Patel.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING Qian Yin, Yuan Tian, Venkataraman Kabaleeswaran, Xiaomo Jiang, Daqi Tu, Michael J.

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial- Mesenchymal Transition Min-Zu Wu, Ya-Ping Tsai, Muh-Hwa Yang, Chi-Hung Huang,

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

Kinase-Independent Function of Cyclin E Yan Geng, Young-Mi Lee, Markus Welcker, Jherek Swanger, Agnieszka Zagozdzon, Joel D. Winer, James M. Roberts, Philipp.

Chapter 5 Cell Division and DNA Replication

Inter-chromosomal Contact Properties in Live-Cell Imaging and in Hi-C

The DNA Damage Response: Ten Years After

Histone Acetylation by HBO1 Tightens Replication Licensing

Structural Insights into Riboswitch Control of the Biosynthesis of Queuosine, a Modified Nucleotide Found in the Anticodon of tRNA Mijeong Kang, Robert.

The Ripoptosome: Death Decision in the Cytosol

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

Saving the Ends for Last: The Role of Pol μ in DNA End Joining

Skill Development in Graduate Education

In This Issue Cell Volume 158, Issue 5, (August 2014)

DNA Polymerases at the Replication Fork in Eukaryotes

The Case of the Disappearing Drug Target

Fungal BRCA2 Ortholog Brh2 Brings 5′ End Strand Invasion Back on Stage

How To Choose a Good Scientific Problem

Triggering Selective Autophagy at the Right Place and the Right Time

AMPK Keeps Tumor Cells from Starving to Death

AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator

Volume 26, Issue 2, Pages (February 2018)

PAF Makes It EZ(H2) for β-Catenin Transactivation

William G. Kaelin, Peter J. Ratcliffe Molecular Cell

Eukaryotic Transcription Activation: Right on Target

An Argonaute Protein Directs Nuclear Xrn2 Function

Volume 64, Issue 5, (December 2016)

Hijacking the DNA Damage Response to Enhance Viral Replication: γ-Herpesvirus 68 orf36 Phosphorylates Histone H2AX Anyong Xie, Ralph Scully Molecular.

MicroRNAs and Viral Infection

TTBK2 Kinase: Linking Primary Cilia and Cerebellar Ataxias

Paradigms for the Three Rs: DNA Replication, Recombination, and Repair

Volume 49, Issue 2, Pages (January 2013)

Volume 58, Issue 6, Pages (June 2015)

Structural Insights into Riboswitch Control of the Biosynthesis of Queuosine, a Modified Nucleotide Found in the Anticodon of tRNA Mijeong Kang, Robert.

Volume 49, Issue 6, Pages (March 2013)

Volume 60, Issue 3, Pages (November 2015)

Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes

The Cell Biology of Genomes: Bringing the Double Helix to Life

Apollo—Taking the Lead in Telomere Protection

Is complement a target for therapy in renal disease?

The DNA Damage Response: Ten Years After

AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator

Volume 54, Issue 5, Pages (June 2014)

How To Choose a Good Scientific Problem

Volume 61, Issue 2, Pages (January 2016)

Christina L. Rosenberger, Jie Chen Molecular Cell

Chaos Controlled: Discovery of a Powerful Amyloid Inhibitor

S-Nitrosylation at the Interface of Autophagy and Disease

Volume 25, Issue 2, Pages (January 2007)

Eric Verdin, Melanie Ott Molecular Cell

New Myc-anisms for DNA Replication and Tumorigenesis?

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

53BP1 Goes Back to Its p53 Roots

Presentation transcript:

Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control Peter K. Jackson Molecular Cell Volume 51, Issue 4, Pages 407-408 (August 2013) DOI: 10.1016/j.molcel.2013.08.013 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control The Nek8/NPHP9 is important in the function of primary cilia and in blocking pediatric renal degeneration in the disease nephronophthisis (NPHP). These ciliary functions of Nek8 are highlighted in red. Nek8 kinase also controls the DNA damage checkpoint through the direct control of cyclin A kinase activity and indirectly via the ATR-Chk1 pathway, thus limiting DNA damage in response to replication stress. Molecular Cell 2013 51, 407-408DOI: (10.1016/j.molcel.2013.08.013) Copyright © 2013 Elsevier Inc. Terms and Conditions