Beta-human Chorionic Gonadotropin-producing Renal Cell Carcinoma

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Presentation transcript:

Beta-human Chorionic Gonadotropin-producing Renal Cell Carcinoma Adewumi N. Adekunle, BS, Austin S. Lam, BS, Sara D. Turbow, MD, MPH, Christina R. Stallworth, MD, Matthew J. Ferris, MD, Jungjin Kim, MD, Terry A. Jacobson, MD The American Journal of Medicine Volume 129, Issue 3, Pages e29-e31 (March 2016) DOI: 10.1016/j.amjmed.2015.10.035 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure (A) Coronal abdominal computed tomography (CT) with contrast shows large mixed cystic/solid lesions in both the right and left kidneys (arrows). (B) Axial abdominal CT with contrast showing bilateral complex masses (asterisks) and enlarged adjacent retrocaval and left perinephric lymph nodes, concerning for local metastatic disease. (C) Axial chest CT demonstrates multiple indeterminate pulmonary nodules. (D) Testicular ultrasound reveals a left hydrocele (asterisk). (E) Fine-needle aspiration (FNA) smear of renal tumor shows cluster of smooth-bordered cells typical of renal cell carcinoma. Cells with bland nuclei and clear cytoplasm favor clear cell type (Diff-quick stain 20×; inset - 40×magnification). (F) FNA smear of renal tumor (Papanicolaou stain, 20×; inset, 40×magnification). (G) FNA smear of renal tumor demonstrates calcifications (arrows) (Papanicolaou stain, 20×). Contrast and brightness of images have been optimized for display. TP53 sequencing showed dup/del and mutation, which does not rule out mutations affecting gene expression or mRNA splicing. The American Journal of Medicine 2016 129, e29-e31DOI: (10.1016/j.amjmed.2015.10.035) Copyright © 2016 Elsevier Inc. Terms and Conditions