The EASI model structured around four modules (exposure (top left), activity (bottom left), severity (top right) and impact (bottom right)), each of which.

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Presentation transcript:

The EASI model structured around four modules (exposure (top left), activity (bottom left), severity (top right) and impact (bottom right)), each of which presents the parameter values used to calculate it and the relevant steady-state activation functions ... The EASI model structured around four modules (exposure (top left), activity (bottom left), severity (top right) and impact (bottom right)), each of which presents the parameter values used to calculate it and the relevant steady-state activation functions linking inputs from previous module (x-axis) to module outputs (y-axis). In the exposure module, the solid line indicates daily smoking exposure (packs per day; left y-axis) as a function of age (x-axis), whereas the dashed line corresponds to the cumulative smoking exposure (pack-years, right y-axis) of that theoretical individual. The EASI model also includes two central panels. The top one presents a longitudinal summary of the age-related trajectories of exposure, activity, forced expiratory volume in 1s (FEV1) (right y-axis) and symptoms. The bottom centre panel presents a heat map of these same four variables by decade of age. This particular example illustrates the EASI relationships for a susceptible continuous smoker. Reproduced with from [69] with permission from the publisher. Alvar Agustí, and Bartolomé Celli ERJ Open Res 2017;3:00117-2017 ©2017 by European Respiratory Society