Long-Term Risk of Ischemic Stroke After the Cox-Maze III Procedure for Atrial Fibrillation Anders Albåge, MD, PhD, Ulrik Sartipy, MD, PhD, Göran Kennebäck,

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Long-Term Risk of Ischemic Stroke After the Cox-Maze III Procedure for Atrial Fibrillation Anders Albåge, MD, PhD, Ulrik Sartipy, MD, PhD, Göran Kennebäck, MD, PhD, Birgitta Johansson, MD, PhD, Henrik Scherstén, MD, PhD, Lena Jidéus, MD, PhD Anders Albåge, MD, PhD, Lena Jidéus, MD, PhD, Göran Kennebäck, MD, PhD, Göran Källner, MD, PhD, Henrik Scherstén, MD, PhD, Lisa Ternström, MD, PhD, Birgitta Johansson, MD, PhD, Anders Ahlsson, MD, PhD, Johan Sjögren, MD, PhD, Gabriella Boano, MD, Farkas Vanky, MD, PhD, Anders Holmgren, MD, Haider Ghaidan, MD Anders Albåge, MD, PhD, Ulrik Sartipy, MD, PhD, Göran Kennebäck, MD, PhD, Birgitta Johansson, MD, PhD, Henrik Scherstén, MD, PhD, Lena Jidéus, MD, PhD Anders Albåge, MD, PhD, Lena Jidéus, MD, PhD, Göran Kennebäck, MD, PhD, Göran Källner, MD, PhD, Henrik Scherstén, MD, PhD, Lisa Ternström, MD, PhD, Birgitta Johansson, MD, PhD, Anders Ahlsson, MD, PhD, Johan Sjögren, MD, PhD, Gabriella Boano, MD, Farkas Vanky, MD, PhD, Anders Holmgren, MD, Haider Ghaidan, MD The Annals of Thoracic Surgery Volume 104, Issue 2, Pages 523-529 (August 2017) DOI: 10.1016/j.athoracsur.2016.11.065 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Cumulative incidence of ischemic stroke/transient ischemic attack (TIA) after the Cox-Maze III procedure in patients with preoperative CHA2DS2-VASc (age in years, sex, congestive heart failure history, hypertension history, stroke/TIA, thromboembolism history, vascular disease history, diabetes mellitus) score 0 or 1 compared with patients with CHA2DS2-VASc score 2 or greater. Note: A competing risk regression model was used to calculate the cumulative incidence function, accounting for the competing risk of death [13]. (CI = confidence interval; HR = hazard ratio.) The Annals of Thoracic Surgery 2017 104, 523-529DOI: (10.1016/j.athoracsur.2016.11.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Cumulative incidence of ischemic stroke/transient ischemic attack (TIA) after the Cox-Maze III procedure (CM-III) in men compared with women (upper panel), in patients who underwent a stand-alone CM-III compared with CM-III concomitant with other cardiac procedures (lower panel). (CI = confidence interval; HR = hazard ratio.) The Annals of Thoracic Surgery 2017 104, 523-529DOI: (10.1016/j.athoracsur.2016.11.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Observed and predicted [14] ischemic stroke rate (% per year) according to CHA2DS2-VASc (age in years, sex, congestive heart failure history, hypertension history, stroke/transient ischemic attack, thromboembolism history, vascular disease history, diabetes mellitus) score in patients who underwent the Cox-Maze III procedure. Note that there were no observed strokes in patients with a CHA2DS2-VASc score greater than 3. The Annals of Thoracic Surgery 2017 104, 523-529DOI: (10.1016/j.athoracsur.2016.11.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions