Azathioprine-Induced Lymphoma Manifesting as Fulminant Hepatic Failure

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Presentation transcript:

Azathioprine-Induced Lymphoma Manifesting as Fulminant Hepatic Failure Humberto I. Aguilar, MD, Lawrence J. Burgart, MD, Alex Geller, MD, Jorge Rakela, MD Mayo Clinic Proceedings Volume 72, Issue 7, Pages 643-645 (July 1997) DOI: 10.4065/72.7.643 Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Abdominal ultrasonogram, showing multiple hypoechoic masses (arrows) within liver. Mayo Clinic Proceedings 1997 72, 643-645DOI: (10.4065/72.7.643) Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Fine-needle aspiration liver biopsy specimen, showing that anaplastic large cell lymphoma cells have effaced liver architecture and totally displaced hepatocytes. Note widespread pleomorphism of neoplastic cells including multinucleated cells. (Hematoxylin-eosin; original magnification, ×400.) Mayo Clinic Proceedings 1997 72, 643-645DOI: (10.4065/72.7.643) Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 Immunoperoxidase stain with use of antibody to CD30 (BerH2), showing uniform, strong membrane staining of lymphoma cells. (Original magnification, ×400.) Mayo Clinic Proceedings 1997 72, 643-645DOI: (10.4065/72.7.643) Copyright © 1997 Mayo Foundation for Medical Education and Research Terms and Conditions