Hepatitis Due to Human Herpesvirus 6 after Hematopoietic Stem Cell Transplantation Joshua A. Hill, MD, Danielle Zerr, MD, MPH, Ruth Hall Sedlak, PhD,

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Hepatitis Due to Human Herpesvirus 6 after Hematopoietic Stem Cell Transplantation Joshua A. Hill, MD, Danielle Zerr, MD, MPH, Ruth Hall Sedlak, PhD, Keith R. Jerome, MD, PhD, David Myerson, MD, PhD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S228-S229 (February 2014) DOI: 10.1016/j.bbmt.2013.12.385 Copyright © 2014 Terms and Conditions

Fig.1 Quantitative plasma human herpesvirus 6 (HHV-6) viral loads (VL) and liver enzyme trends during hospitalization. ALT, alanine aminotransferase; AP, alkaline phosphatase. Biology of Blood and Marrow Transplantation 2014 20, S228-S229DOI: (10.1016/j.bbmt.2013.12.385) Copyright © 2014 Terms and Conditions

Fig. 2 Immunohistochemical staining (brown) of a number of HHV-6 proteins. A) Early antigen (E A) p41 staining in the cytoplasm of hepatocytes and Kupffer cells (20X). Inset shows positively staining bodies in the cytoplasm of hepatocytes (60X) [bar = 100 μM]. B) EA p41 staining of control liver specimen with hemosiderosis showing light background staining in hepatocytes but not in Kupffer cells. C) Viral capsid antigen (VCA) p140 staining in Kupffer cell cytoplasm, and in a punctate distribution in hepatocyte cytoplasm, both with a patchy distribution. D) VCA stained control with hemosiderosis showing minimal background staining. E) Envelope glycoprotein (EG) gH stains similarly to VCA with an identical patchy distribution. F) CD68 staining of the subject liver demonstrating Kupffer cells. Biology of Blood and Marrow Transplantation 2014 20, S228-S229DOI: (10.1016/j.bbmt.2013.12.385) Copyright © 2014 Terms and Conditions