The effect of bisphenol A (BPA) on colon and liver inflammation.

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The effect of bisphenol A (BPA) on colon and liver inflammation. The effect of bisphenol A (BPA) on colon and liver inflammation. Rabbit offspring were exposed in utero or through lactation to either vehicle or BPA (200 μg/kg/day) from gestation day 15 through postnatal day 7, and tissues were collected at 6 weeks of age. (A to D) Representative images of colon and liver sections stained with H&E (scale bars = 25 µm). (A) Normal colonic mucosa in a control pup. The white arrow indicates a normal distribution of lymphocytes (inset: high magnification). (B) Liver parenchyma in a control pup. Lymphocytic infiltration (black arrows) was sparse, which is typical of a normal liver. The asterisk indicates areas of hydropic degeneration with possible accumulation of glycogen in hepatocytes, which was also observed in BPA-exposed offspring (see panel D). (C) Colonic inflammation in a BPA-exposed pup. Black arrows indicate coagulative necrotic changes in mucosal epithelium; the white arrow indicates focal neutrophil and eosinophil infiltration in the lamina propria (inset: high magnification). (D) Liver parenchyma in a BPA-exposed pup showing moderate (grade 2) infiltration of inflammatory cells. Black arrows point to some of the lymphocytes seen in the micrograph. Note that the cytoplasmic features of patches of hepatocytes (asterisk) in this BPA-exposed pup are similar to those seen in the control pup (shown in panel B). (E) Comparison of magnitudes of lesions in the colon. (F) Comparison of magnitudes of lesions in the liver. H&E-stained sections were scored based on a scale of 0 to 3 (0 = no lesions; 3 = severe lesions). (G) Serum lipopolysaccharide (LPS) levels were high in BPA-exposed offspring compared to controls. LPS was measured by the Endochrome-K Kinetic Chromogenic LAL assay. Data are expressed as means ± standard errors of the means (SEM) (n = 9 or 10 rabbit pups per group). The Wilcoxon rank sum test was used to calculate statistical significance. *, P < 0.05 (versus controls). Lavanya Reddivari et al. mSystems 2017; doi:10.1128/mSystems.00093-17