(A) An overview of the JAK/STAT signalling pathway.

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(A) An overview of the JAK/STAT signalling pathway. Figure 1 from S J Thomas British Journal of Cancer (2015) 113, 365-371. doi:10.1038/bjc.2015.233 Several approaches exist to target Eph receptors. Kinase inactivating strategies include kinase inhibitors or blocking peptides or antibodies. Kinase activating strategies include ligand stimulation, activating antibodies or ligand peptide mimetics Strategies to deliver toxic payloads following receptor activation and internalisation include coupling of cytotoxic agents or radionuclides to Eph monoclonal antibodies. © 2015 Cancer Research UK.