JAK's SOCS: A Mechanism of Inhibition

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JAK's SOCS: A Mechanism of Inhibition Akihiko Yoshimura, Hideo Yasukawa Immunity Volume 36, Issue 2, Pages 157-159 (February 2012) DOI: 10.1016/j.immuni.2012.01.010 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Current Model of the Inhibition of JAKs by SOCS3 In a previous model, the KIR domain of SOCS3 (orange) functioned as pseudosubstrate for JAK kinase (purple). In the current model proposed by Babon et al. (2012), based on a structural analysis of the complex, SOCS3 binds to the surface of the JH1 domain, which contains a GQM motif and induces a conformational change of the catalytic pocket, so as to block transfer of a phosphate group to the substrate. KIR is involved in the binding of SOCS3 to JH1. Immunity 2012 36, 157-159DOI: (10.1016/j.immuni.2012.01.010) Copyright © 2012 Elsevier Inc. Terms and Conditions