A Locus on Chromosome 1p36 Is Associated with Thyrotropin and Thyroid Function as Identified by Genome-wide Association Study  Vijay Panicker, Scott G. Wilson, John P. Walsh, J. Brent Richards, Suzanne J. Brown, John P. Beilby, Alexandra P. Bremner, Gabriela L. Surdulescu, Emad Qweitin, Irina Gillham-Nasenya, Nicole Soranzo, Ee M. Lim, Stephen J. Fletcher, Tim D. Spector  The American Journal of Human Genetics  Volume 87, Issue 3, Pages 430-435 (September 2010) DOI: 10.1016/j.ajhg.2010.08.005 Copyright © 2010 The American Society of Human Genetics Terms and Conditions

Figure 1 Manhattan Plots from GWAS of Serum TSH, Free T4, and Free T3 in the Discovery Cohort A value of p < 5.0 × 10−8 is regarded as significant. For each marker, the −log10 of the p value resulting from an association test that evaluates its additive effect on the phenotype is plotted. The American Journal of Human Genetics 2010 87, 430-435DOI: (10.1016/j.ajhg.2010.08.005) Copyright © 2010 The American Society of Human Genetics Terms and Conditions

Figure 2 Association of SNPs at Chromosome 1p36.13 with Serum TSH in the Discovery Cohort and LD Structure, D′, of the Region on the Basis of HapMap CEU Data The American Journal of Human Genetics 2010 87, 430-435DOI: (10.1016/j.ajhg.2010.08.005) Copyright © 2010 The American Society of Human Genetics Terms and Conditions