Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study Valérie Siroux, PhD, Christian Lupinek,

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Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study Valérie Siroux, PhD, Christian Lupinek, MD, Yvonne Resch, PhD, Mirela Curin, PhD, Jocelyne Just, MD, PhD, Thomas Keil, MD, MSc, Renata Kiss, PhD, Karin Lødrup Carlsen, MD, PhD, Erik Melén, MD, PhD, Rachel Nadif, PhD, Isabelle Pin, MD, Ingebjørg Skrindo, PhD, Susanne Vrtala, PhD, Magnus Wickman, MD, PhD, Josep Maria Anto, MD, PhD, Rudolf Valenta, MD, PhD, Jean Bousquet, MD, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 2, Pages 643-654.e6 (February 2017) DOI: 10.1016/j.jaci.2016.05.023 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 IgE and IgG recognition frequencies and intensities for genuine pollen marker allergens from ragweed (Amb a 1) (A), birch (Bet v 1) (B), cypress (Cup a 1) (C), olive/ash (Ole e 1) (D), and timothy grass (Phl p 1) (E) and for cross-reactive pollen allergens timothy grass polcalcin (Phl p 7) (F), birch polcalcin (Bet v 4) (G), timothy grass profilin (Phl p 12) (H), and birch profilin (Bet v 2) (I), and for the Bet v 1–related food allergen from apple (Malus domestica 1) (J) in different regions of France. Shown are the percentages of subjects (y-axes) with IgE (upper panels) and IgG reactivity (middle panels) to the allergens in the different cities of France (x-axes) and the pollen counts in the different areas of France (lower panels). Antibody levels are color-coded and shown in ISU. P values assessing the differences across centers were estimated from the nonparametric Kruskal-Wallis test. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 IgE and IgG recognition frequencies and intensities for genuine pollen marker allergens from ragweed (Amb a 1) (A), birch (Bet v 1) (B), cypress (Cup a 1) (C), olive/ash (Ole e 1) (D), and timothy grass (Phl p 1) (E) and for cross-reactive pollen allergens timothy grass polcalcin (Phl p 7) (F), birch polcalcin (Bet v 4) (G), timothy grass profilin (Phl p 12) (H), and birch profilin (Bet v 2) (I), and for the Bet v 1–related food allergen from apple (Malus domestica 1) (J) in different regions of France. Shown are the percentages of subjects (y-axes) with IgE (upper panels) and IgG reactivity (middle panels) to the allergens in the different cities of France (x-axes) and the pollen counts in the different areas of France (lower panels). Antibody levels are color-coded and shown in ISU. P values assessing the differences across centers were estimated from the nonparametric Kruskal-Wallis test. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 IgE and IgG recognition frequencies and intensities for genuine pollen marker allergens from ragweed (Amb a 1) (A), birch (Bet v 1) (B), cypress (Cup a 1) (C), olive/ash (Ole e 1) (D), and timothy grass (Phl p 1) (E) and for cross-reactive pollen allergens timothy grass polcalcin (Phl p 7) (F), birch polcalcin (Bet v 4) (G), timothy grass profilin (Phl p 12) (H), and birch profilin (Bet v 2) (I), and for the Bet v 1–related food allergen from apple (Malus domestica 1) (J) in different regions of France. Shown are the percentages of subjects (y-axes) with IgE (upper panels) and IgG reactivity (middle panels) to the allergens in the different cities of France (x-axes) and the pollen counts in the different areas of France (lower panels). Antibody levels are color-coded and shown in ISU. P values assessing the differences across centers were estimated from the nonparametric Kruskal-Wallis test. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 IgE and IgG recognition frequencies and intensities for genuine pollen marker allergens from ragweed (Amb a 1) (A), birch (Bet v 1) (B), cypress (Cup a 1) (C), olive/ash (Ole e 1) (D), and timothy grass (Phl p 1) (E) and for cross-reactive pollen allergens timothy grass polcalcin (Phl p 7) (F), birch polcalcin (Bet v 4) (G), timothy grass profilin (Phl p 12) (H), and birch profilin (Bet v 2) (I), and for the Bet v 1–related food allergen from apple (Malus domestica 1) (J) in different regions of France. Shown are the percentages of subjects (y-axes) with IgE (upper panels) and IgG reactivity (middle panels) to the allergens in the different cities of France (x-axes) and the pollen counts in the different areas of France (lower panels). Antibody levels are color-coded and shown in ISU. P values assessing the differences across centers were estimated from the nonparametric Kruskal-Wallis test. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 IgE and IgG recognition frequencies and intensities for respiratory house dust mite allergens derived from mite feces, that is, Der p 1 (A), Der p 2 (B), and Der p 23 (C) and from mite bodies, that is, Der p 10 (D), Der p 11 (E), and Der p 14 (F), respectively. Shown are the percentages of subjects (y-axes) with IgE (upper panels) and IgG (lower panels) reactivity to the allergens in the different cities of France (x-axes). Antibody levels are color-coded and shown in ISU. P values assessing the differences across centers were estimated from the nonparametric Kruskal-Wallis test. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 IgG recognition frequencies and intensities for classical food allergens derived from milk (Bos d 4) (A), egg (Gal d 1) (B), and fish (Gad c 1) (C). Shown are the percentages of subjects (y-axes) with IgG reactivity to the allergens in the different cities of France (x-axes). Antibody levels are color-coded and shown in ISU. P values assessing the differences across centers were estimated from the nonparametric Kruskal-Wallis test. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 IgE and IgG recognition frequencies and intensities in subjects not reporting AIT for ragweed (Am b a1) (A), birch (Bet v 1) (B), Cypress (cup a 1) (C), timothy grass (Phl p 1) (D), houst dust mite (Der p 1) (E), house dust mite (Der p 10) (F), and apple (Mal d 1) (G). Mal d, Malus domestica. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 IgE and IgG recognition frequencies and intensities in subjects not reporting AIT for ragweed (Am b a1) (A), birch (Bet v 1) (B), Cypress (cup a 1) (C), timothy grass (Phl p 1) (D), houst dust mite (Der p 1) (E), house dust mite (Der p 10) (F), and apple (Mal d 1) (G). Mal d, Malus domestica. Journal of Allergy and Clinical Immunology 2017 139, 643-654.e6DOI: (10.1016/j.jaci.2016.05.023) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions