A Sustained Viral Response Is Associated With Reduced Liver-Related Morbidity and Mortality in Patients With Hepatitis C Virus Amit G. Singal, Michael.

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Presentation transcript:

A Sustained Viral Response Is Associated With Reduced Liver-Related Morbidity and Mortality in Patients With Hepatitis C Virus Amit G. Singal, Michael L. Volk, Donald Jensen, Adrian M. Di Bisceglie, Philip S. Schoenfeld Clinical Gastroenterology and Hepatology Volume 8, Issue 3, Pages 280-288.e1 (March 2010) DOI: 10.1016/j.cgh.2009.11.018 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Liver-related mortality rates. (A) Annual liver-related mortality rate in treatment failures for HCV patients with all stages of fibrosis. (B) Annual liver-related mortality rate in treatment failures for HCV patients with advanced fibrosis or cirrhosis. (C) RR of liver-related mortality in patients achieving SVR versus treatment failures among HCV patients with all stages of fibrosis. (D) RR of liver-related mortality in patients achieving SVR versus treatment failures among HCV patients with advanced fibrosis or cirrhosis. Clinical Gastroenterology and Hepatology 2010 8, 280-288.e1DOI: (10.1016/j.cgh.2009.11.018) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 HCC rates. (A) HCC rate in treatment failures for HCV patients with all stages of fibrosis. (B) HCC rate in treatment failures for HCV patients with advanced fibrosis or cirrhosis. (C) RR of HCC in patients achieving SVR versus treatment failures among HCV patients with all stages of fibrosis. (D) RR of HCC in patients achieving SVR versus treatment failures among HCV patients with advanced fibrosis or cirrhosis. Clinical Gastroenterology and Hepatology 2010 8, 280-288.e1DOI: (10.1016/j.cgh.2009.11.018) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Hepatic decompensation rates. (A) Hepatic decompensation rate in treatment failures for HCV patients with all stages of fibrosis. (B) Hepatic decompensation rate in treatment failures for HCV patients with advanced fibrosis or cirrhosis. (C) RR of hepatic decompensation in patients achieving SVR versus treatment failures among HCV patients with all stages of fibrosis. (D) RR of hepatic decompensation in patients achieving SVR versus treatment failures among HCV patients with advanced fibrosis or cirrhosis. Clinical Gastroenterology and Hepatology 2010 8, 280-288.e1DOI: (10.1016/j.cgh.2009.11.018) Copyright © 2010 AGA Institute Terms and Conditions

Figure 4 RR of HCC between patients with primary nonresponse to antiviral therapy versus relapsers. Clinical Gastroenterology and Hepatology 2010 8, 280-288.e1DOI: (10.1016/j.cgh.2009.11.018) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 Map of literature search. Clinical Gastroenterology and Hepatology 2010 8, 280-288.e1DOI: (10.1016/j.cgh.2009.11.018) Copyright © 2010 AGA Institute Terms and Conditions