Volume 149, Issue 2, Pages 278-281 (August 2015) The Hierarchical Model of NAFLD: Prognostic Significance of Histologic Features in NASH  Rohit Loomba  Gastroenterology  Volume 149, Issue 2, Pages 278-281 (August 2015) DOI: 10.1053/j.gastro.2015.06.016 Copyright © 2015 AGA Institute Terms and Conditions

Figure 1 (A) Multivariable-adjusted forest plots showing predictors of increased risk of mortality or liver transplantation. (B) Multivariable-adjusted forest plots showing predictors of increased risk of liver-rated events. (C) The hierarchical model of nonalcoholic fatty liver disease histology. The rank order of the histologic lesions from higher risk of mortality to lower risk of mortality in NAFLD is as follows: Fibrosis is the most important histologic lesion that is associated with long-term outcomes in NAFLD. Among fibrosis stages, it is the presence of advanced fibrosis including bridging (stage 3) and cirrhosis (stage 4) that has the highest risk of mortality, and this increased risk of mortality is not just for liver disease, but also for cardiovascular events. Fibrosis is followed by portal inflammation, the diagnosis of NASH, and presence of ballooning, respectively. Gastroenterology 2015 149, 278-281DOI: (10.1053/j.gastro.2015.06.016) Copyright © 2015 AGA Institute Terms and Conditions