Pronounced facial flushing and persistent erythema of rosacea effectively treated by carvedilol, a nonselective β-adrenergic blocker Chia-Chi Hsu, MD, Julia Yu-Yun Lee, MD Journal of the American Academy of Dermatology Volume 67, Issue 3, Pages 491-493 (September 2012) DOI: 10.1016/j.jaad.2012.04.017 Copyright © 2012 American Academy of Dermatology, Inc. Terms and Conditions
Fig 1 Patient 11. A, Before carvedilol treatment, facial flushing and persistent erythema were treated with doxycycline 100 mg once daily (qd) and dexamethasone 0.5 mg qd. B, After starting carvedilol 3.125 mg 3 times a day (tid) for 2 weeks, then 6.25 mg tid for another 2 weeks, there was significant clinical improvement. C, Further improvement of facial erythema when carvedilol was increased to 25 mg/d. D, Changes of treatment regimen, visual analog scale (VAS) score, and cheek temperature over time. Note transient increase of VAS and cheek temperature when dexamethasone was tapered to 0.25 mg qd. But this flareup was reversed when dose of carvedilol was increased to 25 mg/d. This dose adjustment also allowed cessation of dexamethasone. Journal of the American Academy of Dermatology 2012 67, 491-493DOI: (10.1016/j.jaad.2012.04.017) Copyright © 2012 American Academy of Dermatology, Inc. Terms and Conditions