Figure 3. Schematic representation of co-expression networks for BipA, SidD, and Erg11 encoding genes. Genes are represented by circles, with positive.

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Figure 3. Schematic representation of co-expression networks for BipA, SidD, and Erg11 encoding genes. Genes are represented by circles, with positive and negative correlations depicted by grey and red lines, respectively. For simplicity, protein names are given in the centre of each circle. Where names were not available in A. niger, we used the name for either A. nidulans or S. cerevisiae ortholog. Query genes encoding BipA, SidD, or Erg11 are given in black diamond boxes. Co-expression sub-networks are given for gene pairs passing |0.7| (A) and |0.5| (B) Spearman correlation coefficient cut-offs. Both sub-networks were assessed for enriched GO terms, and genes were manually filtered into functional categories based on these analyses and interrogation of research literature (C). Note that in each instance, hypothetical proteins were co-expressed with each query gene, indicating the encoded products are somehow associated with these biological processes. From: Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks Nucleic Acids Res. Published online November 29, 2018. doi:10.1093/nar/gky1183 Nucleic Acids Res | © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. 1