Characteristics of propofol-evoked vascular pain in anaesthetized rats

Slides:

Advertisements

Similar presentations

O. Moriarty, L. Harrington, S. Beggs, S.M. Walker

Advertisements

Relationship between Bispectral Index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints M. Iannuzzi,

Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation† G.A. Hans, S.M. Lauwick, A.

AnestAssist British Journal of Anaesthesia

Repeat dosing of rocuronium 1

Antiemetic and analgesic-sparing effects of diphenhydramine added to morphine intravenous patient-controlled analgesia T.-F. Lin, Y.-C. Yeh, Y.-H. Yen,

J Barbara, M.-C. Santais, D.A. Levy, F Ruff, F Leynadier

K.-Y. Ho, W Tay, M.-C. Yeo, H Liu, S.-J. Yeo, S.-L. Chia, N.-N. Lo

Leukemia inhibitory factor (LIF) potentiates antinociception activity and inhibits tolerance induction of opioids H.J. Tu, K.H. Kang, S.Y. Ho, H.C. Liou,

G Turner, M.J. Goldacre, T Lambert, J.W. Sear

Electrocardiographic changes during continuous intravenous application of bupivacaine in neonatal pigs J Mauch, A.P.N. Kutter, C Madjdpour, N Spielmann,

Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass E Takizawa, H Hiraoka, D Takizawa,

Does prior administration of enoxaparin influence the effects of levobupivacaine on blood clotting? Assessment using the Thrombelastograph® S.A. Leonard,

L. Pain, A. Launoy, N. Fouquet, P. Oberling

Comparison of coagulation and blood loss during anaesthesia with inhaled isoflurane or intravenous propofol N.L. Law, K.F.J. Ng, M.G. Irwin, J.S.F. Man

A different use of visual analytic techniques in anaesthetics

M. Naguib, D. L. Hammond, P. G. Schmid III, M. T. Baker, J. Cutkomp, L

Intrathecal lidocaine elevates prostaglandin E2 levels in cerebrospinal fluid: a microdialysis study in freely moving rats† V. Umbrain, L. Shi, M.-H.

N.T.M. Jack, E.B. Liem, L.H. Vonho¨gen British Journal of Anaesthesia

J.-Y. Hwang, H.-S. Na, Y.-T. Jeon, Y.-J. Ro, C.-S. Kim, S.-H. Do

Assessment of the cough reflex after propofol anaesthesia for colonoscopy J Guglielminotti, T Rackelboom, A Tesniere, X Panhard, F Mentre, M Bonay, J.

Epidural infusion or combined femoral and sciatic nerve blocks as perioperative analgesia for knee arthroplasty† Davies A.F. , Segar E.P. , Murdoch J.

Chemical encapsulation of rocuronium by synthetic cyclodextrin derivatives: reversal of neuromuscular block in anaesthetized Rhesus monkeys† H.D. de.

Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy A. Agarwal, S. Gautam,

SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain† Y. Niiyama, T. Kawamata, J. Yamamoto,

Intrathecal cyclooxygenase inhibitor administration attenuates morphine antinociceptive tolerance in rats C. -S. Wong, M. -M. Hsu, R. Chou, Y. -Y. Chou,

BIS guided sedation with propofol during spinal anaesthesia: influence of anaesthetic level on sedation requirement Ozkan-Seyhan T. , Sungur M. Orhan.

Randomized, double-blind comparison of patient-controlled epidural infusion vs nurse- administered epidural infusion for postoperative analgesia in patients.

Central cholinergic depletion induced by 192 IgG-Saporin alleviates the sedative effects of propofol in rats L. Pain, H. Jeltsch, O. Lehmann, C. Lazarus,

Recruitment of cardiac parasympathetic activity: effects of clonidine on cardiac vagal motoneurones, pressure lability, and cardiac baroreflex slope in.

Glycopyrrolate during sevoflurane–remifentanil-based anaesthesia for cardiac catheterization of children with congenital heart disease K. Reyntjens,

Complications of peripheral nerve blocks

Efficacy of intravenous magnesium in neuropathic pain

D.M. Mathews, S.S. Rahman, P.M. Cirullo, R.J. Malik

Development of acute tolerance to the EEG effect of propofol in rats†

EEG-controlled closed-loop dosing of propofol in rats

Spasmolytic effects of prostaglandin E1 on serotonin-induced bronchoconstriction and pulmonary hypertension in dogs Y. Hashimoto, K. Hirota, H. Yoshioka,

Amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures S. Inoue, M. Kawaguchi,

Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane R. Sasaki, K. Hirota, S.H. Roth, M. Yamazaki

Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious.

High-dose versus low-dose local anaesthetic for transversus abdominis plane block post-Caesarean delivery analgesia: a meta-analysis S.C. Ng, A.S. Habib,

The novel Kv1.5 channel blocker vernakalant for successful treatment of new-onset atrial fibrillation in a critically ill abdominal surgical patient

Testing of a new pneumatic device to cause pain in humans

Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids† P.M.W. Lam, J. McDonald, D.G. Lambert

Postoperative changes in visual evoked potentials and cognitive function tests following sevoflurane anaesthesia G. Iohom, I. Collins, D. Murphy, I.

H. Gottrup, F.W. Bach, L. Arendt-Nielsen, T.S. Jensen

Suppressive effect of nitrous oxide on motor evoked potentials can be reversed by train stimulation in rabbits under ketamine/fentanyl anaesthesia, but.

Nervus medianus evoked potentials and bispectral index during repeated transitions from consciousness to unconsciousness† I. Rundshagen, J. Mast, N.

Antinociceptive effects of tetrodotoxin (TTX) in rodents

Frequency band of EMG in anaesthesia monitoring

Sou J.-H. , Chan M.-H. , Chen H.-H. British Journal of Anaesthesia

Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values Ezzine S. , Varin.

Effects of short-term simultaneous infusion of dobutamine and terlipressin in patients with septic shock: the DOBUPRESS study† A. Morelli, C. Ertmer,

H Viitanen, P Annila British Journal of Anaesthesia

M Kodaka, Y Okamoto, F Handa, J Kawasaki, H Miyao

Effects of oxytocin on Purkinje fibres

Prostaglandin E2 and aggressive factors increase the gland luminal pressure in the rat gastric mucosa in vivo Ingrid Synnerstad, Lena Holm Gastroenterology

Reduction in mouth opening with semi-rigid cervical collars†

A unique effect of propofol on the jaw opening reflex

Effects of halothane, sevoflurane and propofol on left ventricular diastolic function in humans during spontaneous and mechanical ventilation† Filipovic.

Assessment of pulse transit time to indicate cardiovascular changes during obstetric spinal anaesthesia† G Sharwood-Smith, J Bruce, G Drummond British.

Cross-tolerance between spinal neostigmine and morphine in the rat

Early stages of propofol infusion syndrome in paediatric cardiac surgery: two cases in adolescent girls N. Laquay, P. Pouard, M.A. Silicani, L. Vaccaroni,

I.V. ropivacaine compared with lidocaine for the treatment of tinnitus

M.A. Tooley, C.L. Stapleton, G.L. Greenslade, C Prys-Roberts

Relationship between Bispectral Index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints M. Iannuzzi,

Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery M. Grossherr, A. Hengstenberg,

Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo Inagawa G. , Sato K. , Kikuchi T. , Nishihama.

Minimum effective local anaesthetic dose of isobaric levobupivacaine and ropivacaine administered via a spinal catheter for hip replacement surgery Sell.

Closed-loop control of propofol anaesthesia using bispectral index™: performance assessment in patients receiving computer-controlled propofol and manually.

Presentation transcript:

Characteristics of propofol-evoked vascular pain in anaesthetized rats R Ando, C Watanabe British Journal of Anaesthesia Volume 95, Issue 3, Pages 384-392 (September 2005) DOI: 10.1093/bja/aei184 Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 1 A schematic diagram of recording and analytic methods for assessments of flexor reflex in rats. British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 2 The effect of increasing doses on i.a. propofol- and capsaicin-evoked rectified EMG (lower) in rats showing EMG value (mVs2), latency (s), and duration (s) for each dose (a, b, c) of propofol and capsaicin (upper). British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 3 The effects of pre-treatment with (a) procaine (i.a.) and (b) lidocaine (i.a.) on the i.a. propofol- (left) and capsaicin-evoked (right) EMG responses. **P<0.01 (n=6, Fisher's Protected LSD test). British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 4 Typical tracings of the effects of repeated i.a. injections (at 2-min intervals) of propofol (upper) and capsaicin (lower) on the flexor reflex in rats. British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 5 The effects of pre-treatment with morphine (5 mg kg−1, s.c.) and naloxone (1.5 mg kg−1, s.c.) on i.a. (a) propofol- and (b) capsaicin-evoked EMG responses. *P<0.05, **P<0.01, saline vs morphine; #P<0.01; +P<0.05, morphine vs morphine + naloxone; $P<0.01, saline vs morphine + naloxone (n=6, Fisher's Protected LSD test). British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 6 The effects of arterial pre-treatment with capsazepine (20 μg) on i.a. (a) propofol- and (b) capsaicin-evoked EMG responses. **P<0.01 vs 1% DMSO (n=6, Fisher's Protected LSD test). British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 7 The effects of pre-treatment with indomethacin (INDM, 10 mg kg−1, i.p.) on i.a. (a) propofol- and (b) capsaicin-evoked EMG responses. Prostaglandin E2 (PGE2, 5 μg) was infused arterially 55 min after indomethacin treatment. **P<0.01 vs 0.5% TWEEN 80, indomethacin + prostaglandin E2 (n=5, Fisher's Protected LSD test). British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 8 The potentiating effects of arterial pre-infusion of prostaglandin E2 (PGE2, 5 μg) on i.a. (a) propofol- and (b) capsaicin-evoked flexor reflex responses in rats. The upper illustrations are typical tracings of the rectified EMG. **P<0.01 vs capsaicin (n=5, Mann–Whitney U-test). British Journal of Anaesthesia 2005 95, 384-392DOI: (10.1093/bja/aei184) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions