MONDAY DO NOW Assign Yourself – Homework Packet Due THU 10/20 Biorganizer – Cornell Notes page 50 Title: TYPES OF MUTATIONS DO NOW: TRANSLATION DO NOW (5 min)

Mutations

Why are proteins so important? Proteins determine what a person’s traits (physical features) will be.

Why do people have different traits? People have different traits (like different eye color and hair color) because they have different nucleotide sequences. Different nucleotide sequences result in different types of proteins, which results in different physical traits.

What is a Mutation? the changing of the structure of a gene, resulting in a different form that may be transmitted to succeeding generations

What are the different types of Mutations? Insertion Deletion Frameshift Substitution Silent

Processing Piece #1 What kind of mutation do you think this is? Why? Original DNA: TCACCG Mutation : TCAACCG

Insertion Mutation An insertion mutation is the addition of one or more nucleotide base pairs into a DNA sequence.

Processing Piece #2 What kind of mutation do you think this is? Original DNA: TCACCG Mutation : TCCCG

Deletion Mutation A deletion is a mutation in which part of chromosome or a sequence of DNA is missing. Deletion is the loss of genetic material.

Frameshift Mutation A Frameshift mutation will cause all of the following protein chains to be built incorrectly. EX: Deletion, Insertion

Processing Piece #3 What kind of mutation do you think this is? Original DNA: TCACCG Mutation : TCGCCG

Substitution Mutation A substitution (or Point Mutation) is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide.

Sickle Cell Anemia Sickle Cell Disease is a hereditary disorder characterized by abnormality in the oxygen-carrying hemoglobin molecule in red blood cells.

Silent Mutations Silent mutation are DNA mutation that do not significantly alter the organism.

PRACTICE Original DNA Sequence: T A C A C C T T A Mutated DNA Sequence: T A C A T C T T A Circle the change in the Mutated DNA. What’s the mRNA sequence for the mutated DNA? Amino acid sequence for the Mutated DNA? Will there likely be effects? What kind of mutation is this?

Assign Yourself – NO HOMEWORK IPC Assign Yourself – NO HOMEWORK DO NOW: *Start on Lesson 15 Read Annotate Number the paragraphs State what the paragraph is about Answer the questions All 3 thing must be complete for credit. These grades go in the gradebook.