Mutant p53 in Cancer: New Functions and Therapeutic Opportunities Patricia A.J. Muller, Karen H. Vousden  Cancer Cell  Volume 25, Issue 3, Pages 304-317 (March 2014) DOI: 10.1016/j.ccr.2014.01.021 Copyright © 2014 The Authors Terms and Conditions

Figure 1 Strategies that Are Currently Being Explored to Target Mutant p53 Depicted in red are schematics of the strategies that are currently being explored to target p53 mutant-expressing cancers. These strategies include promotion of mutant p53 degradation through the proteasome and autophagy pathways, restoration of wild-type p53 activity, interference with the interaction between mutant p53 and other proteins, and interference in signaling pathways downstream of mutant p53. Cancer Cell 2014 25, 304-317DOI: (10.1016/j.ccr.2014.01.021) Copyright © 2014 The Authors Terms and Conditions