Volume 68, Issue 6, Pages 996-1003 (December 2015) Survival and Functional Stability in Chronic Kidney Disease Due to Surgical Removal of Nephrons: Importance of the New Baseline Glomerular Filtration Rate  Brian R. Lane, Sevag Demirjian, Ithaar H. Derweesh, Toshio Takagi, Zhiling Zhang, Lily Velet, Cesar E. Ercole, Amr F. Fergany, Steven C. Campbell  European Urology  Volume 68, Issue 6, Pages 996-1003 (December 2015) DOI: 10.1016/j.eururo.2015.04.043 Copyright © 2015 European Association of Urology Terms and Conditions

Fig. 1 Progressive decline in renal function from new baseline glomerular filtration rate (GFR) after surgery for renal cancer. Patients with no CKD or CKD-S have a significantly lower risk of progression then patients with CKD-M/S. The CKD-M/S cohort is further subdivided into those with preoperative stage 3a (n=430, GFR 45–59ml/min/1.73 m2), stage 3b (n=214, 30–44ml/min/1.73 m2), and stage 4 (n=81, 15–29ml/min/1.73 m2) CKD. CKD=chronic kidney disease; CKD-S=CKD due to surgical removal of nephrons; CKD-M/S=CKD due to medical and surgical causes; GFR=glomerular filtration rate; eGFR estimated GFR. European Urology 2015 68, 996-1003DOI: (10.1016/j.eururo.2015.04.043) Copyright © 2015 European Association of Urology Terms and Conditions

Fig. 2 (A) All-cause mortality and (B) non–renal cancer mortality after renal cancer surgery according to CKD group. There are significant differences (p<0.001) between patients with no CKD, CKD-S, and CKD-M/S. The CKD-M/S cohort is further subdivided into those with stage 3a (n=715, 45–59ml/min/1.73 m2), stage 3b (n=366, 30–44ml/min/1.73 m2), and stage 4 (n=153, 15–29ml/min/1.73 m2) CKD. CKD=chronic kidney disease; CKD-S=CKD due to surgical removal of nephrons; CKD-M/S=CKD due to medical and surgical causes. European Urology 2015 68, 996-1003DOI: (10.1016/j.eururo.2015.04.043) Copyright © 2015 European Association of Urology Terms and Conditions

Fig. 3 The 5-yr probability of (A) a ≥50% decline in renal function from new baseline GFR and (B) all-cause mortality according to new baseline GFR. Multivariable analyses adjusted for age, gender, race, diabetes, hypertension, and cardiac disease. Estimates and 95% confidence intervals are indicated for CKD-S and CKD-M/S groups. The risks are higher for CKD-M/S than for CKD-S, and increase when new baseline GFR is less than approximately 45ml/min/1.73 m2. CKD=chronic kidney disease; CKD-S=CKD due to surgical removal of nephrons; CKD-M/S=CKD due to medical and surgical causes; GFR=glomerular filtration rate. European Urology 2015 68, 996-1003DOI: (10.1016/j.eururo.2015.04.043) Copyright © 2015 European Association of Urology Terms and Conditions