Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 by Alma Zernecke, Elisa A. Liehn,

Slides:



Advertisements
Similar presentations
Red blood cells mediate the onset of thrombosis in the ferric chloride murine model by Justin D. Barr, Anil K. Chauhan, Gilbert V. Schaeffer, Jessica K.
Advertisements

Critical role for Syk in responses to vascular injury by Patrick Andre, Toshifumi Morooka, Derek Sim, Keith Abe, Clifford Lowell, Nisha Nanda, Suzanne.
DOI: /j.atherosclerosis
by Johannes B. K. Schwarz, Nicolas Langwieser, Nicole N
Role for Hyaluronan Synthase 3 in the Response to Vascular Injury
Arterioscler Thromb Vasc Biol
Mouse Carotid Artery Ligation Induces Platelet-Leukocyte–Dependent Luminal Fibrin, Required for Neointima Development by Tomihisa Kawasaki, Mieke Dewerchin,
Reduced scar formation in the injured GM of CCR2−/− mice
Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease by Alec A. Schmaier,
A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice by Brian D. Brown, Alessio Cantore, Andrea Annoni, Lucia Sergi Sergi,
Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury by Shahrouz Ghafoory, Rohan Varshney, Tyler Robison, Karim Kouzbari,
A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.
by Cornelia Halin, Nadja E. Tobler, Benjamin Vigl, Lawrence F
by Jordi Xaus, Mònica Comalada, Annabel F
Skovseth et al. Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo. Blood.
Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti–factor VIII immune responses by Ruth A. Ettinger,
A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice by Fernando E. Sepulveda, Sophia Maschalidi,
Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells by Christian P. Kalberer, Uwe Siegler, and Aleksandra Wodnar-Filipowicz.
by Laurent O. Mosnier, Andrew J
Figure 3. Severity of aortic atherosclerosis in apo-E −/− mice with CRF. Aortic plaque area fraction (A), aortic cholesterol content (B), and aortic root.
VCAM-1 siRNA reduces neointimal formation after surgical mechanical injury of the rat carotid artery  Yanming Qu, MD, Xiangen Shi, MD, Hongwei Zhang,
Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells by Wuding Zhou, Hetal Patel, Ke Li, Qi Peng, Marie-Bernadette.
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells by Elke Scandella, Ying Men, Silke Gillessen,
Hyaluronate-Enhanced Hematopoiesis: Two Different Receptors Trigger the Release of Interleukin-1β and Interleukin-6 From Bone Marrow Macrophages by Sophia.
Volume 12, Issue 2, Pages (August 2010)
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression by Rosalba Salcedo, Maria Lourdes.
Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression by Søren Skov, Klaus Rieneck,
Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis by Janka Kisucka, Anil.
Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a by Kayoko Sato, Yasuyuki Imai,
Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper by Haifa Hamdi, Véronique.
Volume 37, Issue 6, Pages (December 2012)
Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model  Jian-Ming Li, MD, Mohammad.
INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.
Molecular Therapy - Methods & Clinical Development
Prmt7 deficiency causes a fiber-type switch toward glycolytic.
International Journal of Cardiology
S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo  Yih-Jer Wu, MD, PhD, Graciela.
CD8α+ DC-deficient mice are highly susceptible to Lm infection in the absence of CD169+ macrophages. CD8α+ DC-deficient mice are highly susceptible to.
CD169+ macrophages play a critical role in mediating innate immune cell reorganization. CD169+ macrophages play a critical role in mediating innate immune.
Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding, or TPA. Melanocytes in Rev3l-deficient epidermis following UV radiation, wounding,
Stat3C/C mice are more prone to Th17 differentiation. A
Robust adaptive immune response against Babesia microti infection marked by low parasitemia in a murine model of sickle cell disease by Woelsung Yi, Weili.
Dermal architecture is defined by an inverse correlation between fibroblast proliferation and ECM deposition Dermal architecture is defined by an inverse.
A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant by Shauna L. French, Claudia Thalmann, Paul F.
GM-CSF–producing γδT cells are involved in the development of EAM
IL-21 is involved in the pathogenesis of EAM
Marcel Scheinman, MD, Enrico Ascher, MD, Gabriel S
Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal.
T exosomes bind MAdCAM-1 via RA-increased integrin α4β7.
Inhibition of VEGFA or macrophage-specific ablation of Vegfa from TIE2hi/VEGFAhi TMEM macrophages reduces vascular permeability and tumor cell intravasation.
Yehuda G. Wolf, MD, Lars M. Rasmussen, MD, Yoav Sherman, MD, Warner P
ILK knockdown decreases mTOR signaling in PKD kidneys.
by Rodrigo Abreu, Frederick Quinn, and Pramod K. Giri
Elysse C. Filipe et al. BTS 2018;3:38-53
Niacin suppresses pro‐inflammatory cytokine expression in macrophages in DSS‐induced colitis in mice Niacin suppresses pro‐inflammatory cytokine expression.
Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and increased T-cell activation. Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and.
Interactions of neutrophil-derived OSM with gp130-containing receptors on endothelial cells enhance P-selectin–dependent rolling in mouse postcapillary.
CO-1686 does not inhibit WT EGFR signaling in vivo and is active in EGFR-mutant transgenic mouse lung cancer models. CO-1686 does not inhibit WT EGFR signaling.
SiRNA directed at Ngn1 inhibited differentiation of inner ear stem cells to β-III tubulin-positive cells. a, Inner ear stem cells treated with siRNA to.
IKKβ protects adipocytes from HFD-induced cell death.
IL-1R deficiency does not protect syngeneic grafts from destruction.
Artificial Zinc-Finger Transcription Factor of A20 Suppresses Restenosis in Sprague Dawley Rats after Carotid Injury via the PPARα Pathway  Zhaoyou Meng,
Double-immunofluorescence labeling of Arg-1 in WT (A) and IL-10−/− (C) mice at 3 (i) and 7 (ii) days postinjury (dpi). Double-immunofluorescence labeling.
The ITGAL promoter is methylated in fibroblasts but not T cells
Volume 3, Issue 1, Pages 8-13 (January 2001)
EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.
Targeting HR via CDK inhibition resensitizes recurrent cultures to temozolomide (TMZ). Targeting HR via CDK inhibition resensitizes recurrent cultures.
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation by Kate A. Markey, Tatjana.
Treg expression of Gata3 plays a major role in controlling dermal fibrosis. Treg expression of Gata3 plays a major role in controlling dermal fibrosis.
Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.
Presentation transcript:

Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 by Alma Zernecke, Elisa A. Liehn, Ji-Liang Gao, William A. Kuziel, Philip M. Murphy, and Christian Weber Blood Volume 107(11):4240-4243 June 1, 2006 ©2006 by American Society of Hematology

CCR5 but not CCR1 deficiency inhibits neointima formation: role of IL-10. CCR5 but not CCR1 deficiency inhibits neointima formation: role of IL-10. (A) Carotid arteries of CCR5+/+apoE–/– and CCR5–/–apoE–/– mice, CCR1+/+apoE–/– and CCR1–/–apoE–/– mice after wire injury. Representative sections stained with pentachrome (scale bars represent 100 μm) and quantification of neointimal areas (right panels, *P < .05) are shown. ○ represents individual mice; ♦, mean ± SEM. (B) Quantification of macrophage content in injured carotid arteries of CCR5+/+apoE–/– and CCR5–/–apoE–/– mice treated with or without blocking IL-10 mAb, and of CCR1+/+apoE–/– and CCR1–/–apoE–/– mice treated with or without blocking IFN-γ mAb (*P < .05). Error bars indicate SEM. (C) Immunofluorescence staining for CCR2 (nuclear DAPI staining as inserts) and (D) SMCs and IL-10 in CCR5+/+apoE–/– mice and CCR5–/–apoE–/– mice (scale bars represent 25 μm). Alma Zernecke et al. Blood 2006;107:4240-4243 ©2006 by American Society of Hematology