Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 by Alma Zernecke, Elisa A. Liehn,

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Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 by Alma Zernecke, Elisa A. Liehn, Ji-Liang Gao, William A. Kuziel, Philip M. Murphy, and Christian Weber Blood Volume 107(11):4240-4243 June 1, 2006 ©2006 by American Society of Hematology

CCR5 but not CCR1 deficiency inhibits neointima formation: role of IL-10. CCR5 but not CCR1 deficiency inhibits neointima formation: role of IL-10. (A) Carotid arteries of CCR5+/+apoE–/– and CCR5–/–apoE–/– mice, CCR1+/+apoE–/– and CCR1–/–apoE–/– mice after wire injury. Representative sections stained with pentachrome (scale bars represent 100 μm) and quantification of neointimal areas (right panels, *P < .05) are shown. ○ represents individual mice; ♦, mean ± SEM. (B) Quantification of macrophage content in injured carotid arteries of CCR5+/+apoE–/– and CCR5–/–apoE–/– mice treated with or without blocking IL-10 mAb, and of CCR1+/+apoE–/– and CCR1–/–apoE–/– mice treated with or without blocking IFN-γ mAb (*P < .05). Error bars indicate SEM. (C) Immunofluorescence staining for CCR2 (nuclear DAPI staining as inserts) and (D) SMCs and IL-10 in CCR5+/+apoE–/– mice and CCR5–/–apoE–/– mice (scale bars represent 25 μm). Alma Zernecke et al. Blood 2006;107:4240-4243 ©2006 by American Society of Hematology