Clinical trials in luminal Crohn's disease: A historical perspective

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Presentation transcript:

Clinical trials in luminal Crohn's disease: A historical perspective Pieter Hindryckx, Filip Baert, Ailsa Hart, Alessandro Armuzzi, Julian Panès, Laurent Peyrin-Biroulet  Journal of Crohn's and Colitis  Volume 8, Issue 11, Pages 1339-1350 (November 2014) DOI: 10.1016/j.crohns.2014.04.007 Copyright © 2014 European Crohn's and Colitis Organisation Terms and Conditions

Figure 1 Timeline with the milestones in clinical trial development in Crohn's disease before the advent on anti-TNF agents. (CT: clinical trial, RCT: randomized controlled trials, NCCDS: National cooperative Crohn's disease study, CDAI: Crohn's disease activity index, ECCDS: European cooperative Crohn's disease study, CDEIS: Crohn's disease endoscopic activity index of severity). Journal of Crohn's and Colitis 2014 8, 1339-1350DOI: (10.1016/j.crohns.2014.04.007) Copyright © 2014 European Crohn's and Colitis Organisation Terms and Conditions

Figure 2 Overview of the evolution of primary endpoints of CTs in luminal CD. Journal of Crohn's and Colitis 2014 8, 1339-1350DOI: (10.1016/j.crohns.2014.04.007) Copyright © 2014 European Crohn's and Colitis Organisation Terms and Conditions

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