Volume 373, Issue 9677, Pages (May 2009)

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Volume 373, Issue 9677, Pages 1780-1788 (May 2009) Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial Dr Kushwin Rajamani, MBBCh, Prof Peter G Colman, MD, Li Ping Li, BMed, Prof James D Best, MD, Merryn Voysey, MBiostat, Michael C D'Emden, FRACP, Prof Markku Laakso, MD, John R Baker, MD, Prof Anthony C Keech, FRACP The Lancet Volume 373, Issue 9677, Pages 1780-1788 (May 2009) DOI: 10.1016/S0140-6736(09)60698-X Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile of amputation study ITT=intention to treat. *Three patients had non-traumatic amputation unrelated to diabetes. The Lancet 2009 373, 1780-1788DOI: (10.1016/S0140-6736(09)60698-X) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 2 Effects of fenofibrate on first and all amputation events HR=hazard ratio. Counts for each category of amputation are shown. *Patients were counted only once within each category but may be included in more than one category if they had more than one type of amputation. If a patient had more than one type of amputation, or more than one of the same type of amputation, only the first event of each type was analysed. †For all events, all amputations for each category are counted (Poisson method): the incidence rate ratio, analogous to the hazard ratio, is plotted. The Lancet 2009 373, 1780-1788DOI: (10.1016/S0140-6736(09)60698-X) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 3 Cumulative risk curves of time to first amputation (minor, major, any) event, by treatment group Patients could be counted in more than one category, but only once per category. The Lancet 2009 373, 1780-1788DOI: (10.1016/S0140-6736(09)60698-X) Copyright © 2009 Elsevier Ltd Terms and Conditions