Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study Tim Christen, MSc, Stella.

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Presentation transcript:

Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study Tim Christen, MSc, Stella Trompet, PhD, Raymond Noordam, PhD, Lisanne L. Blauw, BSc, Karin B. Gast, MD, PhD, Patrick C.N. Rensen, PhD, Ko Willems van Dijk, PhD, Frits R. Rosendaal, MD, PhD, Renée de Mutsert, PhD, J. Wouter Jukema, MD, PhD Journal of Clinical Lipidology Volume 12, Issue 1, Pages 137-144.e1 (January 2018) DOI: 10.1016/j.jacl.2017.10.023 Copyright © 2017 National Lipid Association Terms and Conditions

Figure 1 Associations with 95% confidence intervals (CIs) of SNPs rs1968905, rs247616, and rs12720922 and the genetic risk score composed from these SNPs with serum CETP concentrations in the participants of the Netherlands Epidemiology of Obesity study, men and women aged between 45 and 65 y (n = 5655). Associations are expressed in microgram per milliliter CETP per allele of the SNPs or per unit of the genetic risk score. CETP, cholesteryl ester transfer protein; SNP, single-nucleotide polymorphism. Journal of Clinical Lipidology 2018 12, 137-144.e1DOI: (10.1016/j.jacl.2017.10.023) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 2 Associations between (genetically determined) serum CETP concentrations (microgram per milliliter) and intima-media thickness (micrometer) in men participating in the Netherlands Epidemiology of Obesity study, aged 45 to 65 y (n = 2715). CETP, cholesteryl ester transfer protein; cIMT, carotid intima-media thickness; CVD, cardiovascular disease; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides. Journal of Clinical Lipidology 2018 12, 137-144.e1DOI: (10.1016/j.jacl.2017.10.023) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 3 Associations between (genetically determined) serum CETP concentrations (microgram per milliliter) and intima-media thickness (micrometer) in women participating in the Netherlands Epidemiology of Obesity study, aged 45 to 65 y (n = 2940). CETP, cholesteryl ester transfer protein; cIMT, carotid intima-media thickness; CVD, cardiovascular disease; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides. Journal of Clinical Lipidology 2018 12, 137-144.e1DOI: (10.1016/j.jacl.2017.10.023) Copyright © 2017 National Lipid Association Terms and Conditions

Supplementary Figure 1 Bland–Altman plots representing the difference between repeated cIMT measurements by the absolute mean cIMT of the repeated measurement. Solid lines represent 95% limits of agreement (LA). (A) The intra-observer variation; (B) the inter-observer variation. Journal of Clinical Lipidology 2018 12, 137-144.e1DOI: (10.1016/j.jacl.2017.10.023) Copyright © 2017 National Lipid Association Terms and Conditions

Supplementary Figure 2 Plots representing the absolute difference in repeated cIMT measurements by the mean of the repeated measurements. Gray solid lines represent the 95% confidence intervals of the regression line. (A) The intra-observer variation; (B) the inter-observer variation. Journal of Clinical Lipidology 2018 12, 137-144.e1DOI: (10.1016/j.jacl.2017.10.023) Copyright © 2017 National Lipid Association Terms and Conditions