Supplementary Figure S1

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Supplementary Figure S1 B

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Supplementary Figure S5 B C D

Supplementary Figure S6 B LRP1B relative expression ratio

LRP1B Relative Expression* Supplementary Table S3 Cell Line LRP1B Relative Expression* 2q21 Copy Number DNA Methylation % miR-548a-5p Expression 8q22.3 Copy Number Summary of LRP1B Hits KAT4 -183223 1 94% +2 - Copy number loss - DNA Methylation (complete) ARO -158357 8505C -21603 0% +6 4 - miR overexpression BCPAP -16433 2 +15 miR overexpression (high) K1 -2551 3 +35 6 - Copy number gain - miR overexpression (very high) TPC-1 -1280 6% +56 5 NPA -1241 5% +22 - miR overexpression (high) XTC-1 -1117 77% +11 DNA Methylation (partial) miR overexpression (moderate) C643 -233 7% Copy number loss HTH74 -156 +5 miR overexpression (low)